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20 Cards in this Set

  • Front
  • Back
MOA - Metronidazole
reduced (active) form disrupts DNA causing cell death
Absorption of metronidazole - good, bad, and if so, where?
good absorption in small intestine
DOC for intestinal or extraintestinal Entamoeba histolytica
iodoquinol or paromomycin
PLUS
metronidazole
DOC for asymptomatic Entamoeba histolytica
iodoquinol or paromomycin
Drugs for for Giardia
any antiparasite drug
DOC for Trichomonas
metronidazole
Side effects - metronidazole
disulfiram like reaction
red-brown urine
absorption of iodoquinol - good, bad, and if so, where?
bad (little oral absorption)
side effects - iodoquinol
iodine toxicity (esp itching, dermatitis)
Subacute myelo-optic neuropathy (SMON)
absorption of paromomycin - good, bad, and if so, where?
very bad (100% in feces)
MOA - Nitazoxanide
interferes with pyruvate-ferredoxin oxidoreductase (PFOR) dependent electron transfer reactions (possibly)
DOC for Cryptosporidium (in non-HIV infected patients)
Nitazoxanide
MOA - mebendazole/albendazole, pyrantel pamoate or ivermectin
either binds b-tubulin thereby inhibiting microtubule polymerization - no glucose uptake and cells have no energy (mebendazole); or activates nicotinic receptors (pyrantel pamoate); or acivates a glutamate gated Cl channel (ivermectin)
any of which can essentially paralyze or immobilize the worm and the worm dies
drugs that treat roundworms in the lumen of the GI tract
mebendazole, albendazole, pyrantel pamoate, ivermectin
drugs that treat 'systemic' roundworms - eg cutaneous larval migrans or Strongyloides
albendazole, ivermectin
which anthelmintic is 'okay' to use during pregnancy?
mebendazole
praziquantel
ivermectin
pyrantel pamoate
pyrantel pamoate
MOA - Praziquantel
paralyze worm and destroys tegument of worm
DOC for tapeworms
Praziquantel
DOC for schistosomes
Praziquantel
Which worm drug can cause CNS depression and how?
ivermectin - if it crosses BBB (normally cannot), then it can activate GABA recepeptors (Cl channel) on the brain