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20 Cards in this Set
- Front
- Back
MOA - Metronidazole
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reduced (active) form disrupts DNA causing cell death
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Absorption of metronidazole - good, bad, and if so, where?
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good absorption in small intestine
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DOC for intestinal or extraintestinal Entamoeba histolytica
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iodoquinol or paromomycin
PLUS metronidazole |
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DOC for asymptomatic Entamoeba histolytica
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iodoquinol or paromomycin
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Drugs for for Giardia
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any antiparasite drug
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DOC for Trichomonas
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metronidazole
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Side effects - metronidazole
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disulfiram like reaction
red-brown urine |
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absorption of iodoquinol - good, bad, and if so, where?
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bad (little oral absorption)
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side effects - iodoquinol
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iodine toxicity (esp itching, dermatitis)
Subacute myelo-optic neuropathy (SMON) |
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absorption of paromomycin - good, bad, and if so, where?
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very bad (100% in feces)
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MOA - Nitazoxanide
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interferes with pyruvate-ferredoxin oxidoreductase (PFOR) dependent electron transfer reactions (possibly)
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DOC for Cryptosporidium (in non-HIV infected patients)
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Nitazoxanide
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MOA - mebendazole/albendazole, pyrantel pamoate or ivermectin
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either binds b-tubulin thereby inhibiting microtubule polymerization - no glucose uptake and cells have no energy (mebendazole); or activates nicotinic receptors (pyrantel pamoate); or acivates a glutamate gated Cl channel (ivermectin)
any of which can essentially paralyze or immobilize the worm and the worm dies |
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drugs that treat roundworms in the lumen of the GI tract
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mebendazole, albendazole, pyrantel pamoate, ivermectin
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drugs that treat 'systemic' roundworms - eg cutaneous larval migrans or Strongyloides
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albendazole, ivermectin
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which anthelmintic is 'okay' to use during pregnancy?
mebendazole praziquantel ivermectin pyrantel pamoate |
pyrantel pamoate
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MOA - Praziquantel
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paralyze worm and destroys tegument of worm
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DOC for tapeworms
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Praziquantel
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DOC for schistosomes
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Praziquantel
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Which worm drug can cause CNS depression and how?
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ivermectin - if it crosses BBB (normally cannot), then it can activate GABA recepeptors (Cl channel) on the brain
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