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25 Cards in this Set
- Front
- Back
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Name antimetabolites
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MTX
5 FU 6 MP |
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Name alkylating agents
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Cyclophosphamide
Melphalan Chlorambucil |
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Name drugs that are both anti inflammatory and anti cancer
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MTX + cyclophosphamide
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Name vinca alkaloids
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Vincristine
Vinblastine |
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These drugs cause DNA break, see fragmentation of DNA by electrophoresis of neoplastic cells
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Anti tumor antibiotics - doxorubicin, daunorubicin, bleomycin
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Nucleoside analog that causes anemia
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Zidovudine (AZT)
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MTX targets which phase of cell cycle
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S phase
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This drug interferes with pool of dihydrofolate reductase
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MTX
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SE of MTX
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MYELOSUPPRESSION (thrombocytopenia and leukopenia)
ORAL MUCOSITIS Small bowel ulceration NEPHROTOXICITY --> need to alkylanize urine to prevent nephron damage, hydration before and after HEPATOTOXICITY --> check LFT before |
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What do you do to reverse myelosuppression caused by MTX
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LEUKOVORIN rescue therapy
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What is the main clinical use of MTX
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ALL and other hematologic cancers, not very good activity against solid tumors
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Nucleoside analog that resembles pyrimidines causes cessation of DNA growth
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5 FU
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Enzyme inhibited by 5 FU
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Thymidilate synthase
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Only anti fungal that is nucleoside analog
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Flucytosine
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Which phase is targeted by 5 FU
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S phase
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SE of 5 FU
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Bone marrow suppression, GI (mucositis), liver toxicity, pigmentation of skin, alopecia
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Anti cancer drug that causes PERNICIOUS ANEMIA
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5 FU
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Palliative in advanced colorectal carcinoma, can be used in combination with MTX for solid tumors
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5 FU
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Action of those drugs mimicks radiation
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Alkylating agents
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These drugs produce carbonium ions which is responsible for FNA damage of neoplastic cells
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Alkylating agents
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SE of alkylating agents
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BM toxicity, MUTAGENIC POTENTIAL - long term use associated with secondary neoplasms (lymphomas)
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Metabolite of cyclophosphamide responsible for side effects
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Acrolein
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SE of cyclophosphamide
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BM suppression, NECROTIZING HEMORRHAGIC CYSTITIS (acrolein)
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Clinical use of cyclophosphamide
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CLL, HD, multiple myeloma but main = CLL
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Drugs that interfere with mitosis and inhibit MITOTIC ASSEMBLY
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Vinblastine/vincristine
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