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36 Cards in this Set
- Front
- Back
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these inhibit cell wall synthesis |
beta lactams, vancomycin, penicillin, cephalosporoin
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these inhibit protein synthesis |
tetracyclines, aminoglycosides, macrolides |
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these inhibit nucleic acid function or synthesis |
fluoroquinolones |
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these inhibit metabolism |
sulfonamides and trimethoprimample |
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*cell wall |
BPVCC |
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*protein |
TAM |
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*nucleic acid |
F |
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*metabolism |
ST |
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ADE of Beta lactams
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IgE mediated allergic reactions --> anaphylaxis serum sickness (rash fever) NVD, C. difficile renal - allergic interstitial nephritis neurologic hematogic derm reactions |
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4 tetracyclines
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mino tetra tige (IV only) |
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indications for tetracyclines
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CAP alternative tx syphilis GI ulcer - H. pylori Lyme disease malaria prophylaxis low dose for acne |
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tigecycline is used for ______ only
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bugs resistant to standard tetracyclines - MRSA, VRE, b-lactamase-producing, anaerobes, chlamydiae, mycobacterial
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ADE of tetracyclines
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NVD, bacterial superinfections (C.diff), hepatotoxicity, photosensitivity |
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tetracyclines are contraindicated in pregnancy, lactation, and kids because _________
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it binds to calcium and causes tooth enamel dysplasia and irregularities in bone growth |
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4 aminoglycosides
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tobramycin amikacin streptomycin |
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3 macrolides
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erythromycin azithromycin clarithromycin |
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ADE of macrolides
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NVD, dyspepsia most common with erythromycin, skin rashes, QTc, hypersensitivity based acute cholestatic hepatitis |
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amphotericin B is used for _______ |
systemic mycoses |
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MOA of amphotericin B |
concentration dependent targets fungal cell membrane permeability |
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what must be done before giving amphotericin B? |
3x premed with benadryl, tylenol, steroid SLOW IV |
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ADE of amphotericin B |
infusion related: fever, chills, muscle spasm, NV, HA, HoTN (why we premed) cumulative toxicity: renal toxicity (IV hydration), increased LFTs, anemia r/t decrease in erythropoetin by damaged renal cells |
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indications for -azole antifungal agents |
systemic infections |
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MOA of -azole agents |
IV or ORAL inhibits synthesis of ergosterol & interferes with membrane permeability time dependent fungistatic all have CYP450 interactions absorption impaired by high pH |
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ADE of -azole agents |
NVD rash QTc prlongation hepatotoxicity - caution in liver dysfunction |
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if a patient is on Voriconazole, they should be warned about ________ |
immediate, transient visual disturbances > 30% of patients |
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DOC in esophageal & oropharyngeal candidiasis & used as single dose in vaginal candidiasis |
Fluconazole |
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these are the newest antifungal class |
echinocandins: - FUNGINS IV only |
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MOA of echinocandins |
fungal cell wall synthesis
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ADE of echinocandins |
GI, flushing, rash, increased FLTs, fever, HA, hypersensitivity |
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indications for Griseofulvin |
systemic tx of dermatophytosis of skin & hair given for 2-6 weeks to allow replacement of infected keratin |
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drug interaction of Griseofulvin |
decreases bioavailability of warfarin |
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ADE of Griseofulvin |
HA, confusion, GI, photosensitivity, rash, ETOH!! |
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indication for Terbinafine
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onycomycosis of toe/finger nails daily x12 weeks for toes daily x6 for fingers |
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MOA of Terbinafine |
interferes with ergosterol biosynthesis |
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ADE of Terbinafine |
GI, HA, NV, rash, elevated LFTs |
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