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16 Cards in this Set

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What is the mechanism for Amphotericin B?
Binds ergosterol (unique to fungi); forms membrane pores that allow leakage of electrolytes and disrupt homeostasis.
What is the mechanism for Nystatin?
Binds to ergosterol, disrupting fungal membranes. "Swish and swallow" for oral candidiasis (thrush).
What is the mechanism for "Azoles?" Ex: Fluconazole, ketoconazole, clotrimazole, etc.
Inhibit fungal steroid (ergosterol) synthesis.
What is the mechanism for Flucytosine?
It inhibits DNA synthesis by conversion to flourouracil, which competes with uracil.
What is the mechanism for Caspofungin?
It inhibits cell wall synthesis.
What is the mechanism for Terbinafine?
It inhibits the fungal enzyme squalene epoxidase.
What is the mechanism for Griseofulvin?
It interferes with microtubule function; disrupts mitosis. Deposits in keratin-containing tissues (e.g., nails).
What is the mechanism for Amantadine?
It blocks viral penetration/uncoating; may buffer pH of endosome. Also causes the release of dopamine from intact nerve terminals.
What is the mechanism for Zanamivir, Oseltamivir?
It inhibits influenza neuraminidase.
What is the mechanism for Ribavirin?
It inhibits synthesis of guanine nucleotides by competiitively inhibiting IMP dehydrogenase.
What is the mechanism for Acyclovir?
Preferencially inhibits viral DNA polymerase when phosphorylated by viral thymidine kinase.
What is the mechanism for Ganciclovir?
Phosphorylation by viral kinase; preferencially inhibits CMV DNA polymerase.
What is the mechanism for Foscarnet?
Viral DNA polymerase inhibitor that binds to the pyrophosphate binding site of the enzyme. Does not require activation by viral kinase.
What is the mechanism for HIV therapy Protease inhibitors Saquinavir, ritonavir,indinavir, nelfinavir, and amprenavir?
It inhibitors assemblu pf mew virus by blocking protease enzyme.
What is the mechanism for HIV therapy Reverse transcriptase inhibitors?
Nucleosides: Zidovudine (AZT), didanosine (ddI), zalcitabine (ddC), stavudine (d4T), lamivudine (3TC), abacavir. Non-nucleosides: Nevirapine, delaviridine, efavirenz.
Preferencially inhibit reverse transcriptase of HIV; prevent incorporation of viral genome into host DNA.
What is the mechanism for Interferons?
Glycoproteins from human leukocytes that block various stages of viral RNA and DNA synthesis.