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16 Cards in this Set
- Front
- Back
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block Peptidoglycan cross linking by inhibiting Penicillin blocking proteins
inhibit cell wall synthesis |
Beta Lactams
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Beta Lactams
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-block Peptidoglycan cross linking by inhibiting Penicillin blocking proteins
-inhibit cell wall synthesis -bacteriocidal -spectrum: broad -synergistic with clavulamic acid (Beta lactamase inhibitor) esx penicillin, oxacillin, cephalosporin, imipenem |
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Vancomycin
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prevent murein monomer from incorporating into peptoglycan chain
-inhibit cell wall synthesis -spectrum: only gram positive -bacteriocidal -renal and ototoxic -treatment for oxacillin resistant S. Aureus |
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prevent murien monomer from incorperating into peptidoglycan chain
-renal and ototoxic(hearing loss) |
vancomycin
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-Interfere with translation of mRNA on 30s subunit of ribosome
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Aminoglycosides
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Aminoglycosides
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-inhibit protein synthesis
-Interfere with translation of mRNA on 30s subunit of ribosome -bacteriocidal - works synergistically with cell wall agents -only in aerobic conditions (need lots of energy for active transport) -treats various gram (-) and gram (+) infections -ex. gentamicin, tobramycin |
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Block chain elongation during protein synthesis by binding to 50s subunit
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Macrolides
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Macrolides
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-inhibit protein synthesis
-Block chain elongation during protein synthesis by binding to 50s subunit -bacteriostatic broad; not active against gram negative bacilli -treats community associate pneumonia -ex. azithromycin |
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Block tRNA binding in translation by binding to 30S subunit
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tetracycline
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tetracycline
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-Block tRNA binding in translation by binding to 30S subunit
-bactariostatic -broad: work on both prokaryotes and eukaryotes -treats malaria and prophylaxis |
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Fluroroquinolones
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Inhibit DNA gyrase block DNA replication
-bacteriocidal -narrow: gram (-) -ex. ciprofloxacin -treats community associated pneumonia and Urinary tract infections |
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Inhibit DNA gyrase --> block DNA replication
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Fluroroquinolones
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Trimethoprim/sulfamethoxazole
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Block folic acid syntheisis at 2 places needed for creation of purines
Inhibits folic acids deals with purins (a and g) -bacteriocidal -both prokaryotes and eukaryotes (fungi and protozoa) -ex. Bactram, eptra -treats- Uninary Tract Infection, MRSA, Fungus |
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Block folic acid syntheisis at 2 places needed for creation of purines
Inhibits folic acids deals with purins (a and g) |
Trimethoprim/sulfamethoxazole
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Colistin
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-disrupt cell membrane
-binds to LPS -highly toxic, kidney (renal) -bacteriocidal -only select G negative bacilli (not gram positive) -treatment- only serious infections by g negative bacilli |
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-disrupt cell membrane
-binds to LPS |
Colistin
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