Antiinfectives

Front 1

Aminoglycosides MOA

Back 1

Inhibit bacterial RNA synthesis - bactericidal

Front 2

Aminoglycosides adverse events

Back 2

Nephrotoxicity - increase in BUN and SCr
Ototoxicity

Front 3

Aminoglycoside Examples

Back 3

Amikacin, Gentamicin, Neomycin, streptomycin

Front 4

Penicillins MOA

Back 4

Inhibit cell wall synthesis by binding PBPs - bactericidal

Front 5

Penicillin Adverse events

Back 5

GI, Allergic, Hypokalemia

Front 6

Cephalosporins MOA

Back 6

Inhibit mucopeptide synthesis in bacterial cell wall

Front 7

Cephalosporins Adverse Drug events

Back 7

Hypersensitivity, GI, Seizures, C. Diff colitis

Front 8

Fluoroquinolones MOA

Back 8

inhibit bacterial DNA topoisomerase

Front 9

Fluoroquinolones Adverse drug events

Back 9

GI, CNS, QT prolongation

Front 10

Fluoroquinolones examples

Back 10

Ciprofloxacin, Levofloxacin, Oflaxacin

Front 11

Fluoroquinolones Counseling

Back 11

Don't take antacints, calcium, magnesium, iron at least 2 hour after each dose

Front 12

Macrolides MOA

Back 12

Inhibit RNA synthesis

Front 13

Macrolides ADEs

Back 13

GI, QT prolongation, ototoxicity

Front 14

Macrolides examples

Back 14

Azithromycin, clarithromycin, erythromycin

Front 15

Tetracyclines Spectrum of Activity

Back 15

Respiratory infections, genital infections

Front 16

Tetracyclines counseling

Back 16

Administer with food

Front 17

Tetracyclines ADEs

Back 17

Photosensitivity reactions
Contraindicated in pregnancy, and children
Hepatotoxic
GI intolerance
Antacids decrease GI absorption

Front 18

Tetracyclines examples

Back 18

Doxycycline, Minocycline, Tetraycycline

Front 19

Sulfonamides MOA

Back 19

Interfere with folic acid synthesis

Front 20

Sulfonamides ADEs

Back 20

rash, urticaria

Front 21

Sulfonamides examples

Back 21

Sulfamethizole, sulfamethoxazole