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16 Cards in this Set
- Front
- Back
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atorvastatin
Lipitor |
mech: inhibit HMG CoA Reductase, increase LDL receptors, decrease plasma LDL
more potent for reducing LDL and increasing HDL side effects: GI disturbance, increase in liver enzymes, myopathy contraindications: active liver disease and these drugs: coumadin, cyclosporin, macrolides, amiodarone, HIV protease inhibitors, large amts. grapefruit juice |
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rosuvastatin
Crestor |
mech: inhibit HMG CoA Reductase, increase LDL receptors, decrease plasma LDL
more potent for reducing LDL and increasing HDL side effects: GI disturbance, increase in liver enzymes, myopathy contraindications: active liver disease and these drugs: coumadin, cyclosporin, macrolides, amiodarone, HIV protease inhibitors, large amts. grapefruit juice |
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lovastatin
Mevacor |
mech: inhibit HMG CoA Reductase, increase LDL receptors, decrease plasma LDL
inactive prodrug; hydrolyzed to active form in the gut side effects: GI disturbance, increase in liver enzymes, myopathy contraindications: active liver disease and these drugs: coumadin, cyclosporin, macrolides, amiodarone, HIV protease inhibitors, large amts. grapefruit juice |
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simvastatin
Zocor |
mech: inhibit HMG CoA Reductase, increase LDL receptors, decrease plasma LDL
inactive prodrug; hydrolyzed to active form in the gut side effects: GI disturbance, increase in liver enzymes, myopathy contraindications: active liver disease and these drugs: coumadin, cyclosporin, macrolides, amiodarone, HIV protease inhibitors, large amts. grapefruit juice |
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pravastatin
Pravachol |
mech: inhibit HMG CoA Reductase, increase LDL receptors, decrease plasma LDL
side effects: GI disturbance, increase in liver enzymes, myopathy contraindications: active liver disease and these drugs: coumadin, cyclosporin, macrolides, amiodarone, HIV protease inhibitors, large amts. grapefruit juice |
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cholestyramine
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bile acid binding resin
mech: prevents reabsorption of bile acids from gut -reduce LDL, minor change in HDL, no change in TGs may impair absorption of fat-soluble vitamins (A, D, K) and other drugs side effects: bloating, constipation, heart burn |
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ezetimibe
Zetia |
mech: inhibits cholesterol absorption by enterocytes in small intestines
PK: excreted in feces side effects: allergic reaction, myopathy |
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nicotinic acid
Niacin |
= vitamin B complex
mech: decreases hepatic VLDL secretion best for raising HDL side effects: flushing (minimized with ASA), GI disturbances, liver enzyme elevation contraindications: liver disease, gout, peptic ulcers |
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gemfibrozil
Lopid |
=fibric acid derivative
mech: decreases hepatic VLDL synthesis, increases lipoprotein lipase activity (increasing VLDL clearance) side effects: GI effects, gallstones contraindications: severe renal or liver disease |
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fenofibrate
Tricor |
=fibric acid derivative
mech: decreases hepatic VLDL synthesis, increases lipoprotein lipase activity (increasing VLDL clearance) side effects: GI effects, gallstones contraindications: severe renal or liver disease |
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eicosapentoic acid (EPA)
docosahexaenoic acid (DHA) |
= omega-3-fatty acids
increase arrhythmia threshold, improve endothelial function, reduce platelet aggregation, reduced blood pressure, reduce triglycerids |
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fish oils
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lower triglycerides, increases LDL size, and may improve HDL
good for diabetics |
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Orlistat
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lipase inhibitor: blocks dietary fat absorption in gut
3% weight loss side effects: fecal urgency, reduced fat-soluble vitamin absorption |
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Sibutramine
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inhibits reuptake of norepinephrine and 5-HT (serotonin): depresses appetite
side effects: tachycardia, HTN |
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Phentermine
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sympathomimetic on hypothalamus (appetite control) and increases catecholamine levels (produces sensation of fullness)
side effects: tremor, tachycardia, palpitations, HTN, pulmonary fibrosis use in the short term ONLY |
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Rimonabant
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CB1 cannabinoid receptor antagonist: reduces appetite
side effects: nausea, dizziness, diarrhea, joint pain, anxiety, depression |
