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20 Cards in this Set
- Front
- Back
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Mechanism of Statins – Atorvastatin (Lipitor), Pitavastatin (Livalo), Rosuvastatin (Crestor)
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-Inhibit HMG-CoA Reductase
-↓ cholesterol synthesis in liver -↑ breakdown of LDL cholesterol -↓ synthesis of VLDL -Reduce plaque formation |
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Indications of Statins – Atorvastatin (Lipitor), Pitavastatin (Livalo), Rosuvastatin (Crestor)
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High Cholesterol
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Advantages of Statins – Atorvastatin (Lipitor), Pitavastatin (Livalo), Rosuvastatin (Crestor)
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Pleiotropic effects:
-Improve function of vascular walls -Antiinflammatory, antioxidant effects -Improved plaque stability -Anticoagulant action -↓ morbidity and mortality |
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Disadvantages of Statins – Atorvastatin (Lipitor), Pitavastatin (Livalo), Rosuvastatin (Crestor)
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Liver dysfunction
-Muscle pain, inflammation -Rhabdomyolysis (disintegration of muscles) -P450-related drug interactions -Pregnancy category X |
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Mechanism of Fibric Acids (Fibrates) – Gemfibrozil (Lopid)
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-↑ lipoprotein lipase activity
-↓ triglycerides -↑ VLDL breakdown |
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Indications of Fibric Acids (Fibrates) – Gemfibrozil (Lopid)
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High Cholesterol
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Advantages of Fibric Acids (Fibrates) – Gemfibrozil (Lopid)
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Improves the plaque stability
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Disadvantages of Fibric Acids (Fibrates) – Gemfibrozil (Lopid)
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GI distress
-Gallstones |
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Mechanism of Resins: cholestyramine (Questran)
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-Bind bile acids in GI
-↑ bile acid excretion -↑ liver cholesterol breakdown to replace lost bile acids -↑ LDL receptors in liver |
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Indications of Resins: cholestyramine (Questran)
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Effective in combination
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Advantages of Resins: cholestyramine (Questran)
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Good for the heart
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Disadvantages of Resins: cholestyramine (Questran)
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Constipation
-Impaired drug absorption |
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Mechanism for Niacin (Nicotinic acid, Vitamin B3, Niaspan)
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-↓ fatty acid mobilization from tissue
-↓ formation and secretion of VLDL by liver -↓ LDL -↑ HDL |
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Indications for Niacin (Nicotinic acid, Vitamin B3, Niaspan)
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Effective in combination
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Advantages of Niacin (Nicotinic acid, Vitamin B3, Niaspan)
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Good for heart and more natural. Only one to increase HDL.
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Disadvantages of Niacin (Nicotinic acid, Vitamin B3, Niaspan)
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Cutaneous flush common.
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Mechanism of Inhibitors of intestinal cholesterol absorption – Exetimibe (Zetia)
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Inhibits transport protein that transfers dietary cholesterol across small intestine walls
-↓ LDL-C |
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Indications of Inhibitors of intestinal cholesterol absorption – Exetimibe (Zetia)
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Effective alone or with combination with statins.
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Advantages of Inhibitors of intestinal cholesterol absorption – Exetimibe (Zetia)
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Good for heart.
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Disadvantages of Inhibitors of intestinal cholesterol absorption – Exetimibe (Zetia)
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Potential risk for cancer.
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