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34 Cards in this Set
- Front
- Back
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inhibit Microtubules synthesis
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Benzomidazoles
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Larvicidal and Ovicidal
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Albendazole
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A. cantonensis, Ascariasis, Cutaneous Larva Migrans, Visceral larval migrans, Gnathomiasis, Hookworm (N. americanus, A. duodenale), Hydatid cyst (Echinococcosis), Instestinal Capillariasis, Microsporidial inf, Neurocysterocosis (w. steroids)
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Albendazole
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< 2 years old
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Albendazole
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Only ovicidal
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Mebendazole
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A. cantonenis, Ascariasis, Hookworm, T. orientalis
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Mebendazole
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cirrhosis
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Mebendazole
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Chelating agent of metal ions (not Ca2+)
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Thiabendazole
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Only ovicidal
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Thiabendazole
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Renal Disease
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Thiabendazole
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Inhibit anaerobic metabolism
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Bithionol
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(after meal)
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Bithionol
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Alternative drug = paragonismiasis
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Bithionol
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< 8 years old
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Bithionol
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Microfilariae = organelle damage, apoptosis, alternative surface structure, interfere with processing, stim host immune response
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Diethylcarbamazine
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Longer T1/2 in alkaline urine
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Diethylcarbamazine
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Filariasis and Loiasis (longer to kill adult worms) w/ steroids or antihist; Masonella sterptocerca, (adult and microfilariae killed); Trpical Eosinophilia
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Diethylcarbamazine
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HTN
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Diethylcarbamazine
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Derived from actinomyces paralyzes via binding to glutamate-gated CI ch = increase permeability hyperpolarization
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Ivermectin
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Excretion = feces (intestinal orgs)
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Ivermectin
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Onchocerciasis (reduces load), Strongyloidiasis
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Ivermectin
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<5 years old
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Ivermectin
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Tetracycline; kill Wolachia (intracell symbiont of parasite)
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Doxycycline
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W. bancrofti
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Doxycycline
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Block Ach = paralysis liver worms expelled by peristalsis
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Piperazine
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Oral, urine excretion
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Piperazine
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Ascariasis
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Piperazine
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Hypertension
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Piperazine
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Increase permeability of helminthic membrane to Ca = paralysis (effective for adults)
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Praziquantel
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Do not chew; poor distribution to CNS
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Praziquantel
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Clonorchiasis, Diphylloothriasis (fish tapeworm) = single dose 100%, Hymenolopsis nana, Fasciolopsiasis, Heterophyiasis, Metagonimiasis, Opisthrochiasis, Paragonimaisis, Taeniasis (100%), Schistosomiasis (w/ steroids)
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Praziquantel
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Operating machinery/driving
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Praziquantel
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Release of Ach and block AChase = paralysis/expulsion (not for migratory stages in tissue or ova)
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Pyrantel Pamoate
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Oral (active in GI lumen), fecal excretion
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Pyrantel Pamoate
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