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54 Cards in this Set
- Front
- Back
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Two heavy chains and two light chains
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Ig or B cell receptor
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Antigen-binding domains of a B cell receptor (BCR)
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VH: VL
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Predominant version of T cell receptor in adaptive immunity
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alpha/beta receptor
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Antigen-binding domains of the T cell receptor (TCR)
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V alpha V beta
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Signaling molecules of BCR complex
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Ig alpha and Ig beta
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Signaling molecules of TCR complex
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CD3 and (zeta)
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Complexes of peptide: MHC molecules
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T cell antigen
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Proteins, polysaccharides, lipids, nucleic acids, small chemicals
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B cell antigens
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Cells whose antigen receptors that are both membrane bound and secreted
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BCR/ Immunoglobulins (Ig)
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Portion of Ig molecule that binds antigen
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Fab
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Portion of Ig molecule that binds complement
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Fc
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Portion of Ig molecule that binds to macrophages
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Fc
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Number of antigen binding sites on the TCR
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One
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Most abundant antibody in the bloodstream
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IgG
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IgG heavy chain
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gamma
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Antibody found in GI tract, colostrum, sweat, tears, saliva
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Dimeric IgA
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IgA heavy chain
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alpha
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Pentameric antibody that potently activates complement
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IgM
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IgM heavy chain
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Mu
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Only antibody that crosses the placenta
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IgG
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Major class of antibody directed at helminth infections
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IgE
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IgE heavy chain
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epsilon
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Classes of antibody that serve as BCR on naive B cells
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IgD and IgM
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IgD heavy chain
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delta
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Antibody that activates mast cells
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IgE
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Opsonizing antibodies
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IgG and IgA
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Two classes of Ig that possess a J chain
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IgM and sIgA
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Half-life of IgG
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21 days
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Derivation of antibodies from a single clone of B lymphocytes that have identical antigen specificity
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Monoclonal antibody
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and
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Ig light chains
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Portion of Ig molecule that determines isotype
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Heavy chains
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Activated and differentiated B cell that secretes antibody
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Plasma cell
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Gene segments in variable regions of Ig heavy chain and TCR chain
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V, D, and J
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First recombination event in BCR heavy chain and TCR beta chain
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D-J joining
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Ig light chain and TCR alpha chain gene segments in variable regions
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V and J
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Rearrangement of V, D, and J segments
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Somatic recombination
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Process that ensures expression of BCR with single specificity
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Allelic exclusion
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Change of Ig class but preservation of antigen specificity
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Isotype switching
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Nucleotide changes in variable regions of Ig genes affecting affinity for antigen
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Somatic hypermutation
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Enzymes responsible for somatic recombination
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VDJ recombinase (RAG-1 and RAG-2)
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Number of CDRs in an intact TCR
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Six
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Total number of V-(D)-J combinations
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Combinatorial diversity
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Number of CDRs in an intact BCR
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Six
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Stage of B cell with no detectable recombination events
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Pro-B cell
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Stage of B cell with recombined H chain and RNA and surrogate light chains
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Pre-B cell
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Stage of B cell with IgM expressed on surface
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Immature B cell
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Stage of B cell with IgM and IgD expressed on surface
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Mature B cell
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Stage of T cell with no recombined beta chain
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Double negative thymocyte; Pro-T cell
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Stage of T cell with recombined beta chain and expressed pre-T alpha
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Pre-T cell
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Stage of T cell with expressed TCR and both CD4 and CD8
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Double-positive T cell; immature T cell
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Weak recognition of MHC Class II + self-peptide
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Positive selection for CD4+
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Weak recognition of MHC Class I + self-peptide
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Positive selection for CD8+
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No recognition of MHC + self-peptide
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Failure of positive selection
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Strong recognition of MHC + peptide
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Negative selection
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