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54 Cards in this Set

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Two heavy chains and two light chains
Ig or B cell receptor
Antigen-binding domains of a B cell receptor (BCR)
VH: VL
Predominant version of T cell receptor in adaptive immunity
alpha/beta receptor
Antigen-binding domains of the T cell receptor (TCR)
V alpha V beta
Signaling molecules of BCR complex
Ig alpha and Ig beta
Signaling molecules of TCR complex
CD3 and (zeta)
Complexes of peptide: MHC molecules
T cell antigen
Proteins, polysaccharides, lipids, nucleic acids, small chemicals
B cell antigens
Cells whose antigen receptors that are both membrane bound and secreted
BCR/ Immunoglobulins (Ig)
Portion of Ig molecule that binds antigen
Fab
Portion of Ig molecule that binds complement
Fc
Portion of Ig molecule that binds to macrophages
Fc
Number of antigen binding sites on the TCR
One
Most abundant antibody in the bloodstream
IgG
IgG heavy chain
gamma
Antibody found in GI tract, colostrum, sweat, tears, saliva
Dimeric IgA
IgA heavy chain
alpha
Pentameric antibody that potently activates complement
IgM
IgM heavy chain
Mu
Only antibody that crosses the placenta
IgG
Major class of antibody directed at helminth infections
IgE
IgE heavy chain
epsilon
Classes of antibody that serve as BCR on naive B cells
IgD and IgM
IgD heavy chain
delta
Antibody that activates mast cells
IgE
Opsonizing antibodies
IgG and IgA
Two classes of Ig that possess a J chain
IgM and sIgA
Half-life of IgG
21 days
Derivation of antibodies from a single clone of B lymphocytes that have identical antigen specificity
Monoclonal antibody
 and 
Ig light chains
Portion of Ig molecule that determines isotype
Heavy chains
Activated and differentiated B cell that secretes antibody
Plasma cell
Gene segments in variable regions of Ig heavy chain and TCR  chain
V, D, and J
First recombination event in BCR heavy chain and TCR beta chain
D-J joining
Ig light chain and TCR alpha chain gene segments in variable regions
V and J
Rearrangement of V, D, and J segments
Somatic recombination
Process that ensures expression of BCR with single specificity
Allelic exclusion
Change of Ig class but preservation of antigen specificity
Isotype switching
Nucleotide changes in variable regions of Ig genes affecting affinity for antigen
Somatic hypermutation
Enzymes responsible for somatic recombination
VDJ recombinase (RAG-1 and RAG-2)
Number of CDRs in an intact TCR
Six
Total number of V-(D)-J combinations
Combinatorial diversity
Number of CDRs in an intact BCR
Six
Stage of B cell with no detectable recombination events
Pro-B cell
Stage of B cell with recombined H chain and  RNA and surrogate light chains
Pre-B cell
Stage of B cell with IgM expressed on surface
Immature B cell
Stage of B cell with IgM and IgD expressed on surface
Mature B cell
Stage of T cell with no recombined beta chain
Double negative thymocyte; Pro-T cell
Stage of T cell with recombined beta chain and expressed pre-T alpha
Pre-T cell
Stage of T cell with expressed TCR and both CD4 and CD8
Double-positive T cell; immature T cell
Weak recognition of MHC Class II + self-peptide
Positive selection for CD4+
Weak recognition of MHC Class I + self-peptide
Positive selection for CD8+
No recognition of MHC + self-peptide
Failure of positive selection
Strong recognition of MHC + peptide
Negative selection