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32 Cards in this Set
- Front
- Back
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Processed peptides bound to MHC molecules
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T cell antigens
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Recognition by T cells of peptides bound to one’s own MHC molecules
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MHC restriction
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Cells that capture and present peptides to T cells
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Antigen-presenting cells (APC)
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Dendritic cells, macrophages, B cells
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Professional APC’s
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Another name for immature dendritic cell in the skin
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Langerhans cell
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Transports antigen from epithelia to draining lymph node
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Dendritic cells
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Destination of antigens captured in epithelia and sub-epithelial tissues
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Lymph nodes, MALT, GALT, BALT
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Destination of blood-borne antigens
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Spleen
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Microbial-induced activators of dendritic cells
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TNF, IL-1, TLR signaling
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Destination of dendritic cells in lymph nodes
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T cell zones
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Chemical signal that attracts activated dendritic cells to draining lymph node
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Chemokines that bind to CCR7 on dendritic cell
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Afferent lymphatic vessel—lymph node---efferent lymphatic vessel
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Flow of lymph through a draining lymph node
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Human Major Histocompatibility Complex (MHC) proteins
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Human Leukocyte Antigens (HLA)
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Genes that encode the Class I MHC molecules
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HLA-A, B, C
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Cells that express Class I MHC molecules
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All nucleated cells
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Genes that encode the Class II MHC molecules
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HLA-DP, DQ, and DR
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Cells that express Class II MHC molecules
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Professional APC’s
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Set of MHC alleles present on each chromosome
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MHC haplotype
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MHC molecules that are recognized by CD8+ T cells
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Class I
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MHC molecules that are recognized by CD4+ T cells
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Class II
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Domains of peptide-binding groove of MHC Class I molecules
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alpha1:alpha 2
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CD8 binding site of MHC Class I molecule
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alpha 3
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Domains of peptide-binding groove of MHC Class II molecules
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alpha1:beta1
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CD4 binding site of MHC Class II molecule
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beta2
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Source of antigens for MHC Class I molecules
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Endogenous cytosolic proteins
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Source of antigens for MHC Class II molecules
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Endosomes/Lysosomes
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Site of peptide loading for MHC Class I molecule
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Endoplasmic reticulum
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Site of peptide loading for MHC Class II molecule
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Vesicle
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Enzymes that generate peptides for MHC Class I molecules
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Proteasome
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Enzymes that generate peptides for MHC Class II molecules
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Proteases in vesicles
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T cell population that responds to peptide: MHC Class II molecules
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CD4+ T cells
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T cell population that responds to peptide: MHC Class I molecules
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CD8+ T cells
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