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8 Cards in this Set
- Front
- Back
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Caspofungin |
Use: Invasice candidiasis and aspergillosis IV only Wel;l- tolerated Poor CNS penetration May cause heptotoxicity Inhibits 1, 3, beta glucan synthesis |
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Amphrotericin B |
Binds ergosterol in membranes and creates pores Use: Broad- spectrum for serious fungal infxn. Drug of choice for cryptococcal meningitis AMPHROTERRIBLE- Infusion- related reactions- feveres chills hypotension NEPHROTOXIC |
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Terbinafine (lamisil) |
Use: dermatophytes. nail fungus, jock itch, some ring worm 4+ inhibits squalene epoxidae- makes membrane rigid Can build up in skin, nails, fat. Can be in serum 4-8 weeks after use oral granules with non acidic food |
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Fluconazole |
Superficial and systemic fungal infections Can go into CSF does not treat aspergillosis |
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Intraconazole |
Broad spectrum anti-fungal Does not got into CSF Treats apergillosis DO NOT USE WITH CHF |
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Flucytosine |
Interferes with DNA and RNA metab Use: Systemic fungal infections. Used with amphrotericin to treat cryp men. Adverse: Bone Marrow Suppression DO NOT GIVE TO PREGNANT WOMEN |
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Griseofulvin |
Restricted to dermatophytes and ringworm Binds microtubules treatment must be continued until infected tissue is replaced. Deposits inkeratin precursor cells increases metabolism of warfarin makes BC less effective |
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Pentamide |
Alt treatment dor pneumocystis Jiroveci pneumonia (CPC) and leshmaniasis, african tryanosomaisis Adverse: Nephrotoxic, cardio- fatal arryhtmias hypoglycemia, hepatitis, Pentamide, keep in mind pcp and blood sugar, cardio, nephro |
