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44 Cards in this Set
- Front
- Back
Amphotericin B
-MOA |
Binds sterols in plasma membrane forming pores
|
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Amphotericin B
-PK |
Concentration dependent
Poor absorption IV, topical, oral |
|
Amphotericin B
-Uses |
BROADEST spectrum antifungal
Life-threatening systemic Candida NOT lusitanae (Lusitanae sinks ampho) Invasive aspergillus Cryptococcal meningitis Histoplasmosis Dermatophytic, mucoQT infxn |
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Amphotericin B
-AEs |
Nephtrotoxicity-dital tubule ABCD=ABLC>LAMB
Hypokalemia Fever, chills, vomiting, mm spasm ABCD>>ABLC>LAMB |
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Nystatin
-MOA |
Binds sterols in plasma membrane forming pores
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Nystatin
-PK |
Poor absorption
Topical only |
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Nystatin
-Uses |
Local, oropharyngeal infxn
Vaginal candidiasis |
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Nystatin
-AEs |
Uncommon (topical only)
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Flucytosine
-MOA |
Converted by fungi to active metabolites, inhibits fungal RNA/DNA synthesis
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Flucytosine
-PK |
Good absorption, CNS, renal elimination
PO only Combination |
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Flucytosine
-Uses |
Cryptococcal meningitis
Blastomycoses |
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Flucytosine
-AEs |
Narrow Rx window
Bone marrow toxicity Enterocolitis Rash |
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Griseofulvin
-MOA |
Inhibits microtubules, blocks fungal mitosis, binds keratin
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Griseofulvin
-PK |
Poor absorption, increased w/fatty foods
PO |
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Griseofulvin
-Uses |
Onychomycosis requiring extended Rx
Athletes foot Ringworm |
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Griseofulvin
-AEs |
Low incidence
Allergic syndrome Hepatitis Drug interaxn w/warfarin, phenobarbital Headache |
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Ketoconazole
-MOA |
Inhibits fungal ergosterol synthesis
Selectively inhibits fungal P450 enzymes |
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Ketoconazole
-PK |
Low absorption
PO Topical |
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Koteconazole
-Uses |
MucoQT candidiasis
Coccidioidomycosis Seborrheic dermatitis |
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Ketoconzaole
-AEs |
Narrow Rx window
N/V Interferes w/adrenal/gonadal steroid synthesis Inhibition of human P450 enzymes |
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Miconzaole
Clotrimazole -MOA |
Inhibits fungal ergosterol synthesis, selectively inhibits fungal P450 enzymes
|
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Miconzaole
Clotrimazole -PK |
Extremely poor absorption
Topical |
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Miconzaole
Clotrimazole -Uses |
Topical antifungals
Vulvovaginal candidiasis Dermatophytic infxn Oropharyngeal thrush |
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Miconzaole
Clotrimazole -AEs |
Few to none
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Itraconazole
-MOA |
Inhibits fungal synthesis
|
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Itraconazole
-PK |
Lo BA
PO IV |
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Itraconazole
-Uses |
Most potent azole for systemic infxn
Drug of choice for persistent dermatophytosis Aspergillus (all) Endemic mycosis |
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Itraconazole
-AEs |
Lots of drug interaxn
Negative inotrope dont use in CHF |
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Fluconazole
-MOA |
Inhibits fungal ergosterol synthesis
|
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Fluconazole
-PK |
Good absorption
PO, IV |
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Fluconazole
-Uses |
Candidiasis
Cryptococcal meningitis (Drug of choice) MucoQT candidiasis Prophylactic for BM TPX, AIDs pts |
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Fluconazole
-AEs |
Widest Rx window
Few and mild Ineffective for C. glabrata, C. krusei, Aspergillus |
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Voriconazole
-MOA |
inhibits ergosterol synthesis
|
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Voriconazole
-PK |
Well absorbed
Hepatic metabolism Non linear PK, must monitor |
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Voriconazole
-AEs |
Visual EFX
Hallucinations Hepatotoxicity Drug interaxns |
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Posaconazole
|
PO
Prophylaxis Mold High fat meal Yeasts, molds |
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Naftifine
Terbinafine -MOA |
Inhibits fungal squalene metabolism, decreases ergosterol
Inhibits squalene epoxidase |
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Naftifine
Terbinafine -PK |
High First Pass effect
topical PO |
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Naftifine
Terbinafine -Uses |
Onychomycosis
Most QT mycoses NO Candidiasis |
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Naftifine
Terbinafine -AEs |
Few to none
Stevens-Johnson syndrome Hepatotox Neutropenia |
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Caspofungin
Echinocandin -MOA |
Inhibits Beta(1,3)-D-glucan (cell wall) synthesis
|
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Caspofungin
Echinocandin -PK |
Concentration dependent
Poor absorption IV |
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Caspofungin
Echinocandin -Uses |
Invasive Candidiasis
Aspergilla NOT cryptococcus |
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Caspofungin
Echinocandin -AEs |
Fever, N/V, flushing
Irritation @ injxn site Small increase of liver enzymes Hepatotox, phlebitis |