• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

Card Range To Study

through

image

Play button

image

Play button

image

Progress

1/44

Click to flip

Use LEFT and RIGHT arrow keys to navigate between flashcards;

Use UP and DOWN arrow keys to flip the card;

H to show hint;

A reads text to speech;

44 Cards in this Set

  • Front
  • Back
Amphotericin B
-MOA
Binds sterols in plasma membrane forming pores
Amphotericin B
-PK
Concentration dependent
Poor absorption
IV, topical, oral
Amphotericin B
-Uses
BROADEST spectrum antifungal
Life-threatening systemic
Candida
NOT lusitanae (Lusitanae sinks ampho)
Invasive aspergillus
Cryptococcal meningitis
Histoplasmosis
Dermatophytic, mucoQT infxn
Amphotericin B
-AEs
Nephtrotoxicity-dital tubule ABCD=ABLC>LAMB
Hypokalemia
Fever, chills, vomiting, mm spasm
ABCD>>ABLC>LAMB
Nystatin
-MOA
Binds sterols in plasma membrane forming pores
Nystatin
-PK
Poor absorption
Topical only
Nystatin
-Uses
Local, oropharyngeal infxn
Vaginal candidiasis
Nystatin
-AEs
Uncommon (topical only)
Flucytosine
-MOA
Converted by fungi to active metabolites, inhibits fungal RNA/DNA synthesis
Flucytosine
-PK
Good absorption, CNS, renal elimination
PO only
Combination
Flucytosine
-Uses
Cryptococcal meningitis
Blastomycoses
Flucytosine
-AEs
Narrow Rx window
Bone marrow toxicity
Enterocolitis
Rash
Griseofulvin
-MOA
Inhibits microtubules, blocks fungal mitosis, binds keratin
Griseofulvin
-PK
Poor absorption, increased w/fatty foods
PO
Griseofulvin
-Uses
Onychomycosis requiring extended Rx
Athletes foot
Ringworm
Griseofulvin
-AEs
Low incidence
Allergic syndrome
Hepatitis
Drug interaxn w/warfarin, phenobarbital
Headache
Ketoconazole
-MOA
Inhibits fungal ergosterol synthesis
Selectively inhibits fungal P450 enzymes
Ketoconazole
-PK
Low absorption
PO
Topical
Koteconazole
-Uses
MucoQT candidiasis
Coccidioidomycosis
Seborrheic dermatitis
Ketoconzaole
-AEs
Narrow Rx window
N/V
Interferes w/adrenal/gonadal steroid synthesis
Inhibition of human P450 enzymes
Miconzaole
Clotrimazole
-MOA
Inhibits fungal ergosterol synthesis, selectively inhibits fungal P450 enzymes
Miconzaole
Clotrimazole
-PK
Extremely poor absorption
Topical
Miconzaole
Clotrimazole
-Uses
Topical antifungals
Vulvovaginal candidiasis
Dermatophytic infxn
Oropharyngeal thrush
Miconzaole
Clotrimazole
-AEs
Few to none
Itraconazole
-MOA
Inhibits fungal synthesis
Itraconazole
-PK
Lo BA
PO
IV
Itraconazole
-Uses
Most potent azole for systemic infxn
Drug of choice for persistent dermatophytosis
Aspergillus (all)
Endemic mycosis
Itraconazole
-AEs
Lots of drug interaxn
Negative inotrope dont use in CHF
Fluconazole
-MOA
Inhibits fungal ergosterol synthesis
Fluconazole
-PK
Good absorption
PO, IV
Fluconazole
-Uses
Candidiasis
Cryptococcal meningitis (Drug of choice)
MucoQT candidiasis
Prophylactic for BM TPX, AIDs pts
Fluconazole
-AEs
Widest Rx window
Few and mild

Ineffective for C. glabrata, C. krusei, Aspergillus
Voriconazole
-MOA
inhibits ergosterol synthesis
Voriconazole
-PK
Well absorbed
Hepatic metabolism
Non linear PK, must monitor
Voriconazole
-AEs
Visual EFX
Hallucinations
Hepatotoxicity
Drug interaxns
Posaconazole
PO
Prophylaxis
Mold
High fat meal
Yeasts, molds
Naftifine
Terbinafine
-MOA
Inhibits fungal squalene metabolism, decreases ergosterol
Inhibits squalene epoxidase
Naftifine
Terbinafine
-PK
High First Pass effect
topical
PO
Naftifine
Terbinafine
-Uses
Onychomycosis
Most QT mycoses
NO Candidiasis
Naftifine
Terbinafine
-AEs
Few to none
Stevens-Johnson syndrome
Hepatotox
Neutropenia
Caspofungin
Echinocandin
-MOA
Inhibits Beta(1,3)-D-glucan (cell wall) synthesis
Caspofungin
Echinocandin
-PK
Concentration dependent
Poor absorption
IV
Caspofungin
Echinocandin
-Uses
Invasive Candidiasis
Aspergilla
NOT cryptococcus
Caspofungin
Echinocandin
-AEs
Fever, N/V, flushing
Irritation @ injxn site
Small increase of liver enzymes
Hepatotox, phlebitis