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18 Cards in this Set

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amphotericin B, nystatin
polyenes bind to sterols in cell membranes--damaging membranes
amphotericin B, nystatin
selective toxicity: binding better to ergosterol in fungal membranes than the cholesterol in animal cell membranes
amphotericin B, nystatin
poorly absorbed from GI
amphotericin B
used systemically but toxic
amphotericin B
fungicidal, destroys membrane integrity
nystatin
too toxic for systemic use
nystatin
used topically and for oral fungal infections using "swish and swallow" technique, only toxic if gained systemic access. not absorbed from GI tract, this method doesn't lead to toxicity
nystatin
fungistatic, except at high doses that are not physiologically achievable
fluconazole, ketoconazole
systemic, treats oral dandidiasis (thrush) and other systemic mycoses
fluconazole, ketoconazole
important in patients w/ AIDS who may require chronic suppression of recurrent fungal infections
fluconazole, ketoconazole
can be given orally but heptotoxicity occurs
fluconazole, ketoconazole
inhibits ergosterol synthesis, principally by inhibition of cytochrome P450 14a-demethylase--membrane and cell properties are disturbed
fluconazole, ketoconazole
because hyphae synthesis is inhibited the fungi are more easily phagocytosed by PMNs and macrophages. effect is fungistatic
caspofungin
inhibitors of glucan synthesis
flucytosine
only available antimetabolite drug with antifungal activity
flucytosine
inhibits fungal protein synthesis by replacing uracil with 5-flurouracil in fungal RNA
flucytosine
inhibits thymidylate synthetase via 5-fluorodeoxy-uridine monophosphate and thus interferes with fungal DNA synthesis
flucytosine
fungicidal or static, depending on fungal isolate