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18 Cards in this Set
- Front
- Back
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amphotericin B, nystatin
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polyenes bind to sterols in cell membranes--damaging membranes
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amphotericin B, nystatin
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selective toxicity: binding better to ergosterol in fungal membranes than the cholesterol in animal cell membranes
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amphotericin B, nystatin
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poorly absorbed from GI
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amphotericin B
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used systemically but toxic
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amphotericin B
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fungicidal, destroys membrane integrity
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nystatin
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too toxic for systemic use
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nystatin
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used topically and for oral fungal infections using "swish and swallow" technique, only toxic if gained systemic access. not absorbed from GI tract, this method doesn't lead to toxicity
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nystatin
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fungistatic, except at high doses that are not physiologically achievable
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fluconazole, ketoconazole
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systemic, treats oral dandidiasis (thrush) and other systemic mycoses
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fluconazole, ketoconazole
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important in patients w/ AIDS who may require chronic suppression of recurrent fungal infections
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fluconazole, ketoconazole
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can be given orally but heptotoxicity occurs
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fluconazole, ketoconazole
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inhibits ergosterol synthesis, principally by inhibition of cytochrome P450 14a-demethylase--membrane and cell properties are disturbed
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fluconazole, ketoconazole
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because hyphae synthesis is inhibited the fungi are more easily phagocytosed by PMNs and macrophages. effect is fungistatic
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caspofungin
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inhibitors of glucan synthesis
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flucytosine
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only available antimetabolite drug with antifungal activity
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flucytosine
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inhibits fungal protein synthesis by replacing uracil with 5-flurouracil in fungal RNA
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flucytosine
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inhibits thymidylate synthetase via 5-fluorodeoxy-uridine monophosphate and thus interferes with fungal DNA synthesis
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flucytosine
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fungicidal or static, depending on fungal isolate
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