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17 Cards in this Set
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antifungal drugs name
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polyenes (amphotericin B, nystatin,) azoles - Imidazoles (clotrimazole, miconazole, ketoconazole), triazoles (itraconazole, fluconazole, voriconazole). Echinocandins (caspofungin, micafungin, anidulafungin
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amphotericin B
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broad spectrum, IV SE chills renal tox (admin saline)
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nystatin
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not absorbed from the gut
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azoles
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five membered organic rings
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imidazoles
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two nitrogen rings
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triazoles
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three nitrogen rings
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azole MOA
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inhibit p450 12a demethylase involved in the biosynthesis of ergosterol
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azole SE
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liver tox, esp ketoconazole, nausea and vomiting. Drug interactions
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ketoconazole
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mucosal candidasis and cutaneous mycoses and cushings and prostate cancer
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clotrimazole
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topically OTC vulvovaginal candidasis
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miconazole
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topically OTC vulvovaginal candidasis
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fluconazole
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orally or IV, csf penetration, candidemia or cryptococcal meningitis
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itraconazole
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oral, cryptococcosis, aspergillosis, dose related inotropic effcts potential CHF, don’t use with calcium channel blockers
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voriconazole
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extremely broad spectrum, invasive aspergillosis and resistant candidiasis
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echinocandins MOA
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inhibit 1-3 glycan on fungal cell wall IV only
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echinocandins SE
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minor GI irritation, increased liver enzyme
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what is the drug with the most drug interactions
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ketoconazole
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