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15 Cards in this Set
- Front
- Back
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What is the first choice for systemic mycoses?
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Amphotericin B
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How does Amphotericin B work?
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Binds to the fungal cell membrane and increases its permability
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How is Amphotericin B given?
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IV
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What are the adverse effects of Amphotericin B?
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Infusion Reactions (1 hour long)
(Fever, Chills, Rigors, Headache, and Nausea) Nephrotoxicity |
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What can be done to reduce in the inevitable renal damage with Amphotericin B?
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Infusing 1L of saline on the days of Amphotericin administration
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What are the drug interactions with Amphotericin B?
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Nephrotoxic Drugs
Flucytosine (combination decreases risk of amphotericin toxicity) |
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What drug is prototype of the azole family of drugs?
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Itraconazole
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What are the adverse effects of Itraconazole?
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Cardiac Suppression (returns to normal in 12 hours)
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What azole is used superficially for dermatophytic infections and candidiasis?
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Clotrimazole
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What drug is used for oral therapy of vulvovaginal candidiasis?
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Fluconazole
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What drug is given orally to treat superficial mycoses that is deposited in the keratin precursor cells?
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Griseofulvin
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What topical agent is limited to only candidiasis of the skin?
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Amphotericin B
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What is Nystatin used for?
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Candidiasis infections
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What are the drugs of the allylamines?
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Naftifine
Terbinafine Butenafine |
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What is the mechanism of action of the allylamines?
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Inhibits squalene epoxidase and therefore inhibits synthesis of egosterol
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