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15 Cards in this Set

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What is the first choice for systemic mycoses?
Amphotericin B
How does Amphotericin B work?
Binds to the fungal cell membrane and increases its permability
How is Amphotericin B given?
IV
What are the adverse effects of Amphotericin B?
Infusion Reactions (1 hour long)
(Fever, Chills, Rigors, Headache, and Nausea)
Nephrotoxicity
What can be done to reduce in the inevitable renal damage with Amphotericin B?
Infusing 1L of saline on the days of Amphotericin administration
What are the drug interactions with Amphotericin B?
Nephrotoxic Drugs
Flucytosine (combination decreases risk of amphotericin toxicity)
What drug is prototype of the azole family of drugs?
Itraconazole
What are the adverse effects of Itraconazole?
Cardiac Suppression (returns to normal in 12 hours)
What azole is used superficially for dermatophytic infections and candidiasis?
Clotrimazole
What drug is used for oral therapy of vulvovaginal candidiasis?
Fluconazole
What drug is given orally to treat superficial mycoses that is deposited in the keratin precursor cells?
Griseofulvin
What topical agent is limited to only candidiasis of the skin?
Amphotericin B
What is Nystatin used for?
Candidiasis infections
What are the drugs of the allylamines?
Naftifine
Terbinafine
Butenafine
What is the mechanism of action of the allylamines?
Inhibits squalene epoxidase and therefore inhibits synthesis of egosterol