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30 Cards in this Set

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  • Back
TCAs
amitriptyline
nortiptyline
imipramine
desipramine
clomipramine
SSRI
fluoxetine
sertraline
paroxetine
fluvoxamine
mechanism of action of antidepressants
inhibition of uptake of 5-HT and or NE
production of cardiac side effects of TCA is due to
blocaked of ion channels like VANaC
theraputic doses of TCA produce side effects:
sedation
insomnia
tremor
higher doses of TCA produce side effect:
orthostatic hyptension
reflex tach
direct cardiac toxicity
cholinergic blockade
weight gain
used for OCD
clomipramine
ipramine or triptyline suffix
TCA
fluoxetine
prototypic SSRI
no alpha 1 adrenergic, muscarinic, or histaminergic activity
no effect on cardiac contractility and conduction
cns active, lipid soluble
long half life
side effects of SSRI
nausea, insomnia, sexual,
possible effect of combining SSRI with MAOI
serotonin syndrome
which is more effective at treating severe depression SSRI or TCA
TCA
which produces no hypotension, weight gain, sedation, anticholinergic or significant cardiac SE... SSRI or TCA
SSRI
which has a larger therapeutic index... SSRI or TCA
SSRI
venlafaxine
SNRI
reboxetine
NRI
buproprion
atypical AD
related to amphetamine/releases SA
stimulant
effective in depression assocaited with psychomotor retardation
AD used to treat nicotine withdrawel
buproprion
MAOIs
phenelzine
tranylcypromine
drug interactions with MAOI
wine and cheese syndrome
sympathomimetic amine
serotonin syndrome with SSRI
serotonin syndrome
MAOI plus SSRI
hyperthermia, muscle rigidity, myoclonis
which antidepressent suppresses REM sleep and can be used in narcolepsy
MAOI
Li
mood stabilizing drug
inhibits activity of phosphatase that hydrolyzes inositol 2 or 1 phosphate, depleting the stores of PIP2
reducing the effect of transmitters and hormones that act by activating PLC
excretion of lithium is lowered by what?
anything that causes promotion of Na reabsorption by kidney (na restriction, water depletion, hypovolemia, duretics)
Li eliminated by kidney and reabsorped in proximal tubule
uses of lithium
manic episode acute treatment
prophlaxis of manic depressives
alternative to lithium
carbamazepine
valproate
valproate
alternative to Li
carbamazepine
alternative to Li
tyramine
intereacts with MAOI to produce wine and cheese syndrome
indirectly acting sympathomimetic amine
ephedrine
interacts with MAOI
wine and cheese syndrome
indirectly acting sympathomimetic amine