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30 Cards in this Set
- Front
- Back
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TCAs
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amitriptyline
nortiptyline imipramine desipramine clomipramine |
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SSRI
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fluoxetine
sertraline paroxetine fluvoxamine |
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mechanism of action of antidepressants
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inhibition of uptake of 5-HT and or NE
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production of cardiac side effects of TCA is due to
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blocaked of ion channels like VANaC
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theraputic doses of TCA produce side effects:
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sedation
insomnia tremor |
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higher doses of TCA produce side effect:
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orthostatic hyptension
reflex tach direct cardiac toxicity cholinergic blockade weight gain |
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used for OCD
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clomipramine
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ipramine or triptyline suffix
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TCA
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fluoxetine
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prototypic SSRI
no alpha 1 adrenergic, muscarinic, or histaminergic activity no effect on cardiac contractility and conduction cns active, lipid soluble long half life |
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side effects of SSRI
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nausea, insomnia, sexual,
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possible effect of combining SSRI with MAOI
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serotonin syndrome
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which is more effective at treating severe depression SSRI or TCA
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TCA
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which produces no hypotension, weight gain, sedation, anticholinergic or significant cardiac SE... SSRI or TCA
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SSRI
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which has a larger therapeutic index... SSRI or TCA
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SSRI
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venlafaxine
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SNRI
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reboxetine
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NRI
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buproprion
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atypical AD
related to amphetamine/releases SA stimulant effective in depression assocaited with psychomotor retardation |
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AD used to treat nicotine withdrawel
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buproprion
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MAOIs
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phenelzine
tranylcypromine |
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drug interactions with MAOI
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wine and cheese syndrome
sympathomimetic amine serotonin syndrome with SSRI |
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serotonin syndrome
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MAOI plus SSRI
hyperthermia, muscle rigidity, myoclonis |
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which antidepressent suppresses REM sleep and can be used in narcolepsy
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MAOI
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Li
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mood stabilizing drug
inhibits activity of phosphatase that hydrolyzes inositol 2 or 1 phosphate, depleting the stores of PIP2 reducing the effect of transmitters and hormones that act by activating PLC |
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excretion of lithium is lowered by what?
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anything that causes promotion of Na reabsorption by kidney (na restriction, water depletion, hypovolemia, duretics)
Li eliminated by kidney and reabsorped in proximal tubule |
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uses of lithium
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manic episode acute treatment
prophlaxis of manic depressives |
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alternative to lithium
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carbamazepine
valproate |
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valproate
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alternative to Li
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carbamazepine
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alternative to Li
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tyramine
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intereacts with MAOI to produce wine and cheese syndrome
indirectly acting sympathomimetic amine |
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ephedrine
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interacts with MAOI
wine and cheese syndrome indirectly acting sympathomimetic amine |
