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12 Cards in this Set

  • Front
  • Back
Sulfonylureas
MOA
- stimulate insulin release from beta cells of pancreas
- reduce serum glucagon
- increase insulin binding to receptor
Sulfonylureas
how excreted
liver and kidney
Sulfonylureas
contraindications
- patients with hepatic and renal insufficiency
- pregnant animals (depletes fetal insulin)
Meglitinide analogs
how used?
- as postprandial glucose regulators
- used w/ other hypoglycemics drugs (ex Metformin)
Meglitinide analogs
excretion and contraindications
- bile
- patients w/ hepatic inpairment
Metformin
what does it do?
-increases glucose uptake
-sensitizes tissue to insulin action
-reduces hepatic gluconeogenesis
-slows intestinal glubose reabsorption
Metformin
side effects
how excreted
-GI disturbances
-kidney
Glitazones
have what effect
- sensitize target tissue to insulin
-lower insulin resistance
Glitazones
side effects
hepatotoxicity and edema
alpha glucosdase inhibitors
cannot be used with what drug?
metformin (decreases bioavailablity)
alpha glucosdase inhibitors
side effects
flatulence, diarrhea, abdominal cramps
alpha glucosdase inhibitors
MOA
- inhibits alpha glucosdase -> inhibits oligosaccharide hydrolysis
- inhibits secretion of alpha amylase from pancreas -> inhibit starch breakdown