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29 Cards in this Set
- Front
- Back
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Amitriptyline
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TCA
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Nortriptyline
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TCA
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Imipramine
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TCA
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Desipramine
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TCA
Drug interaction w/ Fluoxetine (Prozac). - Fluoxetine inhibits CYP2D6 preventing desipramine from being metabolized --> heart block |
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Clomipramine
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TCA
good for OCD - anxiolytic |
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Doxepin
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TCA
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Amoxapine
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TCA - actually a heterocyclic but whatever
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Phenelzine
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MAOI - irreversible
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Tranylcypromine
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MAOI - reversible
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Selegiline
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MAOI - selective for MAO-B (DA). also anti-parkinsons.
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Fluoxetine
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SSRI
aka Prozac SRI NRI 2D6inh 3A4inh 5HT2C -most activating, may cause aggitation DI: Desipramine + Fluoxetine: 2D6 Codeine + Fluoxetine: 2D6 |
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Fluvoxamine
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SSRI
aka Luvox SRI 1A2inh 3A4inh |
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Sertraline
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SSRI
aka Zoloft SRI DRI - most diarrhea of SSRI's |
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Escitalopram
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SSRI
aka Lexapro SRI only - most selective so least side fx |
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Citalopram
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SSRI
SRI only - most selective so least side fx |
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Paroxetine
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SSRI
aka Paxil SRI NRI mACH-antagonist 2D6inh 3A4inh - anticholinergic fx b/c mACH antagonist - causes most drowsiness of SSRI's |
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Buproprion
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NDRI - primarily DA
aka Wellbutrin/Zyban -preferred over SSRI for ppl that are depressed & bipolar - no SRI side effects Advantages: - mood stabilizing - no sexual dysfunction - no weight gain - smoking cessation Disadvantages: - no help w/ anxiety, possibly anxiogenic - increased risk of seizure, esp in bulimics |
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Venlafaxine
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SNRI
"side effexor" Short 1/2 life and High efficacy so more side effects Adv: - Superior efficacy in some - Rapid onset Disadv: - HTN b/c NRI - increased early side effects - Discontinuation syndrome - OD more problematic than SSRI b/c cardiovascular system affected |
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Nefazodone
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SARI - SE antagonist and reuptake inhibitor
Adv: - sleep enhancing - sexual dysfunction and weight gain rare (b/c SE antagonism at spinal cord) - good for anxiety disorders Disadv: - drug interactions - BID dosage - alpha-1 effects: sleepy & hypotension -->dizzy - rare liver toxicity |
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Mirtazapine
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NaSSA - NE antagonist & SE antagonist
- also blocks H-1 --> increased hunger and sedation -only anti-nausea antidepressant - good for cancer & AIDS pts Advs: -anti-emetic - rapid onset - sleep aid Disadv: - weight gain - sedation - dry mouth - constipation |
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Alprazolam
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BZ
highly potent, use small dose |
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Lorazepam
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BZ
highly potent, use small dose |
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Chlordiazepoxide
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BZ
long 1/2 life used for alcohol w/drawal |
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Clonazepam
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BZ
long 1/2 life, good for chronic use high potent, use small dose |
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Oxazepam
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BZ
long 1/2 life used for alcohol w/drawal and pts w/ liver disease b/c metabolized by kidney, not liver |
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Buspirone
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5HT1A partial agonist
anxiolytic adv: - no problems w/ abuse or w/drawal - good for GAD, alcoholics, drug addicts, ppl w/ cognitive impairments w/ behavioral discontrol disadv: 2 weeks to see effects |
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Propranolol
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adrenergic blocker - Beta blocker
-performance anxiety and PTSD - also migraine preventative |
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Clonidine
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Adrenergic blocker - alpha receptor agonist (activates inhibitor of neg feedback)
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Prazosin
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adrenergic blocker - alpha receptor antagonist
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