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40 Cards in this Set
- Front
- Back
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HIV incidence with blood transfusion:
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1 in 2 million
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2,3,DPG returns to normal:
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12-24 hours post transfusion
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Hep C progresses to chronic in:
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85%
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Hazards of blood transfusion include all of the following except:
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hypercalcemia
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Thromboelastogram measures:
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mechanical properties of a clot
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Alternative to Heparin in pt w/HIT
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Lepirudin (also bivalirudin, and Hirudin)
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Plavix inhibits:
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ADP
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Pradaxa is a:
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direct thrombin inhibitor
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Tissue factor:
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Factor III
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Vitamin K factors all except:
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Factor I
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Longest half life of vitamin K dependent clotting factors:
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Factor II
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Thrombin to _____ to _____ to do what?
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Thrombin to Fibrinogen
Fibrinogen to Fibrin Fibrin --> solidify the clot |
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Pt. gets 21,000 units of heparin and ACT is 250, what is your next action?
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Give add’l 5,000-10,000 units of heparin.
For CPB therapeutic ACT is >450 Normal ACT is 90-120 |
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A thromboelastogram measures:
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mechanical performance of evolving clot (Barash)
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The incidence of transfusion related HIV infection is:
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1 in about 2 million (actual answer is 1 in 1,780,000 from Barash)
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Hepatitis C has a commonly mild initial presentation that:
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progresses to a chronic state in 85% of patients with significant mortality (Barash)
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Thrombin converts fibrinogen to fibrin and activates XIII.
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CF XIII cross links fibrin to solidify the clot.
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Vitamin K works on all the following clotting factors EXCEPT (something like this)
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Clotting Factor I. Vit K works on 2, 7, 9, 10
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Pradaxa is a:
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Direct Thrombin Inhibitor
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Patient is going for a CABG and you give 21,000U of heparin. 10 minutes later you check an ACT and it is 250. What is your next action?
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Give an additional 5,000-10,000 units
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Plavix works on:
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ADP
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What is the major reason for ABO incompatibility?
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Human Error (Barash)
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What is another name for TISSUE FACTOR?
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CF III
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In dosing Protamine Sulfate , 1mg of protamine will bind approximately _______unit(s) of heparin?
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100
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Adverse effects of protamine include all of the following except?
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Hypertension
(Protamine causes hypotension from histamine release / vasodilation) |
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Which of the following would be at most risk of protamine hypersensitivity reaction?
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A 62 year old female with, mitral valve replacement, IDDM on NPH and arrhythmias
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Aspirin may be correctly described as?
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A potent Cyclooxygenase inhibitor
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Virchows triad compromise?
• Damage to venous wall • Change in flow • Blood hypercoagulability • None of the above • All of the above |
All of the above
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Deficiency of protein C and S will cause?
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Hypercoagulation
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Which of the following is not a side effect of labetalol?
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Bronchodilation
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Which of the following classes of antibiotics can cause ototoxicity?
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Aminoglycosides
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The PT will give the information about the coagulation in the following pathways?
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Extrinsic and Common
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(Off Topic!)
Which of the following statements is true about propranolol: |
**Decrease the clearance of bupivacaine**
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In dosing Heparin 10 mg of heparin will equal to?
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1,000 units
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The class of medication categorized as an anticoagulant would include all of the following except?
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Streptokinase (this is a thrombolytic)
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Heparin binds to which of the following cascade components?
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Antithrombin III
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Activating clotting time (ACT) was measured for a CABG patient prior to receiving heparin a normal non-coagulated state would be?
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100 sec (90-120 seconds)
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A CABG patient who is undergoing bypass without induced hypothermia and will require?
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More frequent ACT measurements
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A 70kg patient has received an initial heparin dose of 21,000 units, ten minutes after the heparin was administered the ACT measurement is 250 sec. your next action should be?
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Administer an additional 5000 - 10,000 units of heparin
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Longest half life of vitamin K dependent clotting factors:
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Factor II
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