Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
|
For the intrinsic pathway, which of the following is true: 1) Tissue factor complexes with factor 7 (VII) 2) Kallekrein complexes with factor 12 (XII) 3) Calcium and vitamin K are critical to factors 2, 7, 9, 10 |
2) The key to clotting factors is knowing which agents are in the common pathway, extrinsic pathway, and intrinsic pathway. The intrinsic pathway begins with factor 12, then activates factor 11, then activates factor 9 which is part of the common pathway. Factor 12 is activated after complex forms with kallekrein. |
|
|
For the extrinsic pathway, which of the following is true:
1) Tissue factor complexes with factor 7 (VII) 2) Kallekrein complexes with factor 12 (XII) 3) Calcium and vitamin K are critical to factors 2, 7, 9, 10 |
1) The key to clotting factors is knowing which agents are in the common pathway, extrinsic pathway, and intrinsic pathway. The extrinsic pathway begins with factor 3 where peripheral blood vessels leak tissue factor (III). This complexes with factor 7 (VII) to activate factor 10 which is part of the common pathway. |
|
|
For clotting, which of the following is essential: 1) Tissue factor complexes with factor 7 (VII) and tissue factor is needed to form clots 2) Kallekrein complexes with factor 12 (XII) and kallekrein is needed to form clots 3) Calcium and vitamin K are critical to factors 2, 7, 9, 10 and calcium and vitamin k are needed to form clots |
3) Calcium and vitamin K are critical to factors 2, 7, 9, 10 to promote clot formation. Factor 2 (II), also known as prothrombin, is the foundation of a clot after tissue damage. All factors after X (those excluding extrinsic and intrinsic pathways) join to activate prothrombin into thrombin (IIa). Thrombin activates fibrinogen (I) and fibrin stabilizing factor (XIII) to form a fibrin clot. Either intrinsic or extrinsic pathways can be used to get a clot |
|
|
For the common pathway, which of the following is true: 1) Tissue factor complexes with factor 7 (VII) 2) Kallekrein complexes with factor 12 (XII) 3) Calcium and vitamin K are critical to factors 2, 7, 9, 10 4) Both intrinsic and extrinsic factors converge at Christmas factor (IX) to promote clot formation |
4) The key to clotting factors is knowing which agents are in the common pathway, extrinsic pathway, and intrinsic pathway. Factor IX, or Christmas factor, joins VII of the extrinsic pathway to promote clot formation by activating factor X, the Stuart Power factor in the common pathway. This cascade leads to activation of thrombin II which activates fibrinogen I to form insoluble fibrin. |
|
|
Why would a novel anticoagulant drug target von Willebrand's factor? 1) it is a major regulator of clotting that is depending on calcium and requires carboxylation and cleavage to form an active serine protease to degrade V and VIII preventing prothrombin formation 2) it is a serine protease inhibitor binding II, VII, IX, X, XI, XII and XIII 3) it is an essential cofactor in II, VII, IX, and X and is essential in chelation of carboxylic factors to bring catalytic centers of active factors close to the cleavage site of inactive factor 4) it allows adhesion of platelets to damaged tissue |
4) von Willebrand's factor allows for platelets to aggregate in open wounds during tissue damage. |
|
|
Why would a novel anticoagulant drug target protein C? 1) it is a major regulator of clotting that is depending on calcium and requires carboxylation and cleavage to form an active serine protease to degrade V and VIII preventing prothrombin formation 2) it is a serine protease inhibitor binding II, VII, IX, X, XI, XII and XIII 3) it is an essential cofactor in II, VII, IX, and X and is essential in chelation of carboxylic factors to bring catalytic centers of active factors close to the cleavage site of inactive factor 4) it allows adhesion of platelets to damaged tissue |
1) Protein C is a major regulator of clotting that is depending on calcium and requires carboxylation and cleavage to form an active serine protease to degrade V and VIII preventing prothrombin formation. To date, no drugs have been made to target protein C |
|
|
Why would a novel anticoagulant drug target calcium? 1) it is a major regulator of clotting that is depending on calcium and requires carboxylation and cleavage to form an active serine protease to degrade V and VIII preventing prothrombin formation 2) it is a serine protease inhibitor binding II, VII, IX, X, XI, XII and XIII 3) it is an essential cofactor in II, VII, IX, and X and is essential in chelation of carboxylic factors to bring catalytic centers of active factors close to the cleavage site of inactive factor 4) it allows adhesion of platelets to damaged tissue |
3) Calcium is an essential cofactor in II, VII, IX, and X activation and is essential in chelation of carboxylic factors to bring catalytic centers of an active factor close together with the cleavage site of an inactive factor in order to activate it |
|
|
Why would a novel anticoagulant drug target antithrombin? 1) it is a major regulator of clotting that is depending on calcium and requires carboxylation and cleavage to form an active serine protease to degrade V and VIII preventing prothrombin formation 2) it is a serine protease inhibitor binding II, VII, IX, X, XI, XII and XIII 3) it is an essential cofactor in II, VII, IX, and X and is essential in chelation of carboxylic factors to bring catalytic centers of active factors close to the cleavage site of inactive factor 4) it allows adhesion of platelets to damaged tissue |
2) Antithrombin is a serine protease inhibitor binding II, VII, IX, X, XI, XII and XIII. Binding of antithrombin to these factors and inhibition of their activity requires heparin. |
