Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
Heparin
|
Activates antithrombin III, decreases thrombin & factor Xa.
Intrinsic pathway inhibitor, increases PTT more than PT. Short half-life. Does not cross placenta. Antidote = protamine sulfate |
|
Warfarin
|
Inhibits synthesis & gamma-carboxylation of vit K dependent factors (II, VII, IX, X, prot C, prot S).
Crosses placenta (teratogen). Inhibits extrinsic pathway, increases PT. Antidote = vitamin K, fresh frozen plasma |
|
Aspirin
|
Irreversibly inhibits COX-1 and COX-2.
Increased bleeding time. No change to PT, PTT. SE: ulcers, bleeding, hyperventilation, Reye's syndrome, tinnitus (CN8) |
|
Clopidogrel, Ticlopidine
|
Inhibits platelet aggregation. Irreversibly blocks ADP receptors, blocks GP IIb/IIIa expression.
SE: ticlopidine = neutropenia |
|
Abciximab
|
Inhibits platelet aggregation, antibody to GP IIb/IIIa receptors.
SE: thrombocytopenia |
|
tPA, urokinase, streptokinase, anistreplase
|
Thrombolytics, aid conversion of plasminogen to plasmin and cleaves thrombin/fibrin clots.
Antidote = aminocaproic acid (fibrinolysis inhibitor) |