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6 Cards in this Set

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  • Back
Heparin
Activates antithrombin III, decreases thrombin & factor Xa.

Intrinsic pathway inhibitor, increases PTT more than PT.

Short half-life. Does not cross placenta.

Antidote = protamine sulfate
Warfarin
Inhibits synthesis & gamma-carboxylation of vit K dependent factors (II, VII, IX, X, prot C, prot S).

Crosses placenta (teratogen).

Inhibits extrinsic pathway, increases PT.

Antidote = vitamin K, fresh frozen plasma
Aspirin
Irreversibly inhibits COX-1 and COX-2.

Increased bleeding time. No change to PT, PTT.

SE: ulcers, bleeding, hyperventilation, Reye's syndrome, tinnitus (CN8)
Clopidogrel, Ticlopidine
Inhibits platelet aggregation. Irreversibly blocks ADP receptors, blocks GP IIb/IIIa expression.

SE: ticlopidine = neutropenia
Abciximab
Inhibits platelet aggregation, antibody to GP IIb/IIIa receptors.

SE: thrombocytopenia
tPA, urokinase, streptokinase, anistreplase
Thrombolytics, aid conversion of plasminogen to plasmin and cleaves thrombin/fibrin clots.

Antidote = aminocaproic acid (fibrinolysis inhibitor)