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123 Cards in this Set

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  • Back
What controls the amount of clotting in a vessel? (2)
1. inhibition of platelet adhesion.
2. inhib. of coag cascade and fibrin production
Degine anticoagulants.
chemicals released from endothelial cells which prevent coagulation
The body produced 2 anticoagulants:
heparin
antithrombin III
Heparin and ______ III block active factors IX, X, XII.
antithrombin
Heparin and antithrombin III block active factors ____, ____, and ____
IX, X, XII.
______ and antithrombin III block active factors IX, X, XII.
Heparin
Protein C inhibits factors ____ and VIII.
factors V
Protein C inhibits factors V and ______ .
VIII
______ inhibits factors V and VIII.
Protein C
Protein C is a ______.
anticoagulant
Coumarin anticoagulants act by:
blocking the action of Vit K a cofactor in the synthesis of factors II, VII, IX and X.
To keep blood from clotting in tube use ______.
anticoagulants which remove free Ca ions from plasma
Acetylsalicylic acid prevents:
platelet plug formationn
Acetylsalicylic acid inhibits ______ enzymes, which promote syn of platelet activator thromboxane.
COX
Acetylsalicylic acid inhibits COX enzymes, which promote syn of platelet activator ______.
thromboxane
Aspirin prevents clots by
blocking platelet aggregation
Hemophilia A, factor ____deficiency.
VIII
most common type
sex linked
Hemophilia B, factor ____ deficiency.
IX
Blood is composed of ______ and cellular elements.
plasma
Blood is composed of plasma and ______ elements
cellular elements
______ is composed of plasma and cellular elements
Blood
Plasma is composed of ______, ions, organic molecules, trace elements and vitamins, gases.
water
Plasma is composed of water, ______, organic molecules, trace elements and vitamins, gases.
ions
Plasma is composed of water, ions, ______ molecules, trace elements and vitamins, gases.
organic
Plasma is composed of water, ions, organic molecules, ______ elements and vitamins, gases.
trace
Plasma is composed of water, ions, organic molecules, trace elements and ______, gases.
vitamins
Plasma is composed of water, ions, organic molecules, trace elements and vitamins, ______.
gases
P______ is composed of water, ions, organic molecules, trace elements and vitamins, gases.
Plasma
Proteins name 3 types
Albumin
Globulins
Fibrinogen
Examples of organic molecules
amino acids
proteins
glucose
lipids
nitrogenous wastes
Gases such as:
CO2
O2
formed elements such as:
RBCs
WBCs
Platelets
5 WBCs
lymphocytes
monocytes
neutrophils
eosinophils
basophils
Red blood cells (RBCs) aka
erythrocytes
White blood cells (WBCs) aka
Leukocytes
only the ______ cells are fully functional cells in the circulation.
white
Platelets are cell fragments of ______.
megakaryocyte
RBCs play a key role in Ox and CO2 transport between the ______ and ______.
lungs and tissues
Platelets instrumental in ______.
Coagulation
albumins source
liver
Allbumins function:
colloid osmotic pressure of plasma
carriers for various substances
Globulins source:
liver and lymphoid tissue
Globulins function:
clotting factors
enzymes
antibodies
carriers
Fibrinogen source:
liver
Fibrinogen functions:
forms fibrin threads essential to clotting
Monocytes that leave the circulation and enter tissues become ______.
Macrophages.
tissue basophils are called ______.
Mast cells
Neutrophils, monocytes and macrophages are known as______.
phagocytes
Leukocytes also known as:
immunocytes
Basophils, eosinophils and neutrophils are know as ______.
granulocytes
Single precursor blood cell type:
pleuripotent hematopoietic stem cell
pleuripotent hematopoietic stem cells found in _______.
bone marrow
Hematopoiesis is controlled by c______, growth factors and interleukins.
cytokines
Hematopoiesis is controlled by cytokines, ______ factors and interleukins
growth
Hematopoiesis is controlled by cytokines, growth factors and ______.
interleukins
Cytokines.
Erythropoietin (EPO) produced in ______.
kidney cells
Cytokines.
Thrombopoietin (TPO) produced in ______.
liver primarily
Cytokines.
Erythropoietin (EPO) influences growth or differentiation of
RBCs
Cytokines.
TPO influences growth or differentiation of
Magakaryocytes
Cytokines
Colony-stimulating factors, interleukins, stem cell factor. Source:
Endothelium
fibroblasts of bone marrow
leukocytes
Cytokines
Colony-stimulating factors, interleukins, stem cell factor. Influences growth or diffentiation of:
all types blood cells
mobilizes hematopoitic stem cells
CSFs required to induce both cell ______ and cell maturation to stem cells.
devision
CSFs required to induce both cell devision and cell maturation to ______ cells.
stem
Leukocyte production is regulated in part by ______.
Existing WBCs
Diseases characterized by abnormal growth and development of WBCs:
leukemias
Neutropenia
too few WBCs
Thrombopoietin regulates ______.
platelet production
Stimulus for EPO in kidney is ______.
hypoxia
RBCs live about______ months.
4
Iron comes from the ______.
Diet
Fe absorbed by ______ transport.
active
_______ protein transports Fe in plasma.
Transferrin
Liver stores excess Fe as ______.
ferritin
Bone marrow uses Fe to make______.
Hb
Spleen converts Hb to ______,
bilirubin
Liver metabolizes bilirubin and excretes it as ______.
bile
Bilirubin metabolites are excreted in the ______ and ______.
urine and feces
Hyperbilirubinism aka
Jaundice
Leukocyte production is regulated in part by ______.
Existing WBCs
Diseases characterized by abnormal growth and development of WBCs:
leukemias
Neutropenia
too few WBCs
Thrombopoietin regulates ______.
platelet production
Stimulus for EPO in kidney is ______.
hypoxia
RBCs live about______ months.
4
Iron comes from the ______.
Diet
Fe absorbed by ______ transport.
active
_______ protein transports Fe in plasma.
Transferrin
Liver stores excess Fe as ______.
ferritin
Bone marrow uses Fe to make______.
Hb
Spleen converts Hb to ______,
bilirubin
Liver metabolizes bilirubin and excretes it as ______.
bile
Bilirubin metabolites are excreted in the ______ and ______.
urine and feces
Hyperbilirubinism aka
Jaundice
Leukocytes also known as:
immunocytes
Basophils, eosinophils and neutrophils are know as ______.
granulocytes
Single precursor blood cell type:
pleuripotent hematopoietic stem cell
pleuripotent hematopoietic stem cells found in _______.
bone marrow
Hematopoiesis is controlled by c______, growth factors and interleukins.
cytokines
Hematopoiesis is controlled by cytokines, ______ factors and interleukins
growth
Hematopoiesis is controlled by cytokines, growth factors and ______.
interleukins
Cytokines.
Erythropoietin (EPO) produced in ______.
kidney cells
Cytokines.
Thrombopoietin (TPO) produced in ______.
liver primarily
Cytokines.
Erythropoietin (EPO) influences growth or differentiation of
RBCs
Cytokines.
TPO influences growth or differentiation of
Magakaryocytes
Cytokines
Colony-stimulating factors, interleukins, stem cell factor. Source:
Endothelium
fibroblasts of bone marrow
leukocytes
Cytokines
Colony-stimulating factors, interleukins, stem cell factor. Influences growth or diffentiation of:
all types blood cells
mobilizes hematopoitic stem cells
CSFs required to induce both cell ______ and cell maturation to stem cells.
devision
CSFs required to induce both cell devision and cell maturation to ______ cells.
stem
Red blood cells (RBCs) aka
erythrocytes
White blood cells (WBCs) aka
Leukocytes
only the ______ cells are fully functional cells in the circulation.
white
Platelets are cell fragments of ______.
megakaryocyte
RBCs play a key role in Ox and CO2 transport between the ______ and ______.
lungs and tissues
Platelets instrumental in ______.
Coagulation
albumins source
liver
Allbumins function:
colloid osmotic pressure of plasma
carriers for various substances
Globulins source:
liver and lymphoid tissue
Globulins function:
clotting factors
enzymes
antibodies
carriers
Fibrinogen source:
liver
Fibrinogen functions:
forms fibrin threads essential to clotting
Monocytes that leave the circulation and enter tissues become ______.
Macrophages.
tissue basophils are called ______.
Mast cells
Neutrophils, monocytes and macrophages are known as______.
phagocytes