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27 Cards in this Set
- Front
- Back
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What cell stage is chemotherapy designed to target?
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Dividing stage
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What is the nadir?
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The lowest value of the cell count before recovery.
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What is the the concept of the nadir?
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This is the amount of time required for the effective killing of the cells and then allowing cells to recover to be targeted again.
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What are neutropenic precautions?
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-Strict hand hygeine
-No fresh food or flowers -Mark should be worn -Stay at home, avoid kids -No kitty litter -Use soft toothbrush -WASH HANDS FREQUENTLY |
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What are the basic side effects of chemotherapy?
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-Myelosuppression
-Mucositis -N/V/D/C -Alopecia -Fatigue |
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What are the toxicities that can occur with chemotherapy?
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-Cardiotoxicity
-Pulmonary fibrosis -Nephrotoxicity -Hemorrhagic cystitis -Neurotoxicity -Hepatoxicity -2nd Malignancy |
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What are the side effects of cyclophosphamide (Cytoxin)?
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*Myelosuppression
*Hemmorhagic cystitis -Moderate N/V -50% alopecia -Dermatitis -decreases libido *Teratogenesis |
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What are the nursing implications for cyclophosphamide (Cytoxin)?
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-Always do pregnancy tests
*Push fluids *Void frequently -Administration of MENSA (to coat bladder) prior to dose -Take early in the day *Treats secondary sex characteristics -Nadir 7-14 days |
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What are the side effects of doxorubicin (Adriamycin)?
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-N/V/D
-Stomatitis -100% alopecia *Cardiotoxicity -Extravasation *Photosensitivity *Red-orange urine and body fluids |
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What are the nursing implications for doxorubicin (Adriamycin)?
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*Cumulative lifetime dose is 500 mg/m2
-Reinforce oral care -Avoid sun exposure/use SPF -Educate pt about urine discoloration -Nadir 10 - 14 days |
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What drug is known as the "Red Devil" and why?
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doxorubicin (Adriamycin)
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What are the side effects of fluouracil (5-FU and Xeloda)
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-Myelosuppression
-Stomatitis -N/V/D -severe- -Thinning of hair *Hyperpigmentation of the vein and hyperpigmentation with sun exposure *Hand/Foot syndrome - itching, numbing, tingling, redness, burning of hands or feet |
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What are the side effects of docetaxel (Taxotere)?
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*Known for its 1st dose hypersensitivity reaction
-Fluid retention *Neurotoxicity -Skin/nail changes *Severe neutropenia |
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What are the nursing implications for docetaxel (Taxotere)?
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*Premedicate with Decadron beginning 1-3 days prior
*Always administer where 02 is available -Weigh daily -Assess neurotoxicity before giving (Can you pick up a dime?) |
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What are the side effects for vincristine (Oncovin)?
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-Dose should NEVER exceed 2 mg
*May cause peripheral neuropathy, alopecia, constipation, paralytic ileus, jaw pain, and foot drop (think NERVES) -Unexplained ability to cause a sudden release of platelets from the bone marrow -Extravasation |
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What are the nursing implications for vincristine (Oncovin)?
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-Reduce the dose in the presence of live disease to prevent hepatotoxicity
-Give with stool softeners/laxatives to prevent constipation -Bowel sounds |
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How does bevacizamub (Avastin) work?
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Binds to and inhibits the activity of human vascular endothelial growth factor (VegF) blocking formation of new blood vessels.
-Starves tumor |
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What are the nursing implications for Avastin?
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-Monitor BP
-Give first doses over 1-2 hours, subsequent over 30 min -Avoid use for 28 days after surgery -Very expensive |
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What are the side effects of filgrastim (Neupogen)?
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*Bone Pain
*Decreased platelet count -Changes in liver function |
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What are the nursing implications for filgrastim (Neupogen)?
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*Keep Refrigerated
*Do not shake *Administer at room temp -Educate about bone pain |
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What is the indication for filgrastim (Neupogen)?
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Low WBC
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What is the indication for epoetin alfa (Epogen; Procrit)?
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Anemia caused by cancer chemotherapy and chronic renal failure
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What are the side effects of epoetin alfa (Epogen; Procrit)?
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-Pain at injection site (burning feeling)
-N/V/D -HA -Edema -Fever -HTN |
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What are the nursing implications for epoetin alfa?
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*Do not shake
*Keep -Initiate when Hgb is <12.9% -Stop treatment if HCT is >40% |
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What is Cyclosporine?
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A drug used for solid organ transplants, given IV with a line devoted to it.
-Inhibits T cell activity |
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What is CellCept?
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A drug used for renal or heart transplant, stem cell, and bone marrow transplants.
-NO MEALS |
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What is Immuran?
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A drug used for transplants. Suppresses T-cell and B-cell response and is teratogentic and hepatoxic.
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