Anticancer Drugs

Front 1

Which class of drugs causes Veno-Occlusive Dz of the Liver?

Back 1

Alkylating agents

Front 2

MOA of Alkylating agents?

Back 2

alkylate DNA and form Cross-links and strand breaks

Front 3

cyclophospamide causes what unique adverse effect due to accumulated acrolein?

Back 3

hemorrhagic cystitis

Front 4

These drugs are good for Brain tumors because they are lipophilic and cross the BBB readily.

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Back 4

Carmustine and Lomustine

Front 5

Cisplatin uses of what type of cancer?

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Back 5

Testicular, Ovarian, and bladder cancer

Front 6

Cisplatin is active in what type of environments typically found in urine and inside of cells

Back 6

low chloride environments

Front 7

Cisplatin adverse effect in the CNS?

Back 7

motor and sensory neuropathies and ototoxicity.

Front 8

MOA of Methotrexate?

Back 8

inhibits DHFR which blocks use of folate (antifolate)

Front 9

Methotrexate use?

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Back 9

leukemia and lymphoma, breast CA, Psoriasis and RA

Front 10

Too much Methotrexate can cause the need for what?

Back 10

Lecovorin Rescue to replinish the intracellular pool of tetrahydrofolate cofactors.

Front 11

Methotrexate Adverse effects?

Back 11

GI ulcers, mucusitis, BMD

Front 12

What drug topically treats basal cell Carcinoma?

Also treats breast and colorectal cancer

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Back 12

5-Fluorouracil

Front 13

MOA of 5-Fluorouracil?

Back 13

decrease TTP and inhibit DNA synthesis

Front 14

Uses of Cytarabine

Back 14

Hematological CA:
AML, ALL, and non-Hodgkin's lymphoma

Front 15

Cytarabine must be converted to what before it is active?

Back 15

ara-C

Front 16

Uses of Gemcitabine

Back 16

breast, nonsmall cell lung CA, pancreatic, and ovarian

Front 17

6-Mercaptopurine & 6- thioguanine uses?
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Back 17

ALL, AML, CML

Front 18

6-Mercaptopurine & 6- thioguanine MOA?

Back 18

inhibit synthesis of purine nucleotides

Front 19

6-Mercaptopurine & 6- thioguanine when used with allopurinol what must be done?

Back 19

decrease dosage b/c the 6-...drugs are metabolized by Xanthine Oxidase which is what allopurinol blocks.

Front 20

Vincristine and Vinblastine MOA?

Back 20

antimitotic by binding to Beta-tubulin and inhibiting microtubule polymerization

Front 21

Vincristine uses?

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Back 21

**DOC** to induce remission in Lymphocytic leukemia
(leukemias and lymphomas)

Front 22

Vincristine intrathecally???

Back 22

FATAL

Front 23

Vinblastine uses?

Back 23

Hodgkin's and non-Hodgkin's Lymphomas, testicular CA, Breast CA, Kaposi's Sarcoma

Front 24

Paclitaxel MOA

Back 24

Keeps cell stuck in metaphase by binding to tubulin and not allowing them to break down, activates apoptosis

Front 25

Doxetaxel MOA

Back 25

Keeps cell stuck in metaphase by binding to tubulin and not allowing them to break down, activates apoptosis

Front 26

Paclitaxel Uses

Back 26

Breast and Ovarian CA
Non-small cell Lung CA

Front 27

Docetaxel Uses

Back 27

breast CA, nonsmall cell lung, prostate CA, gastric adenocarcinoma, squamous cell head & neck CA

Front 28

Etoposide MOA

Back 28

inhibits topoisomerase II causing DNA damage.

Front 29

Etoposide Uses

Back 29

refractory testicular tumors and SMALL CELL LUNG CANCER

Front 30

Topotecan and Irinotecan

MOA:

Uses:

Back 30

MOA: Topoisomerase I inhibitors
Uses:
Topotecan- Ovarian and Small cell lung CA
Irinotecan- Metastatic Colon CA

Front 31

Irinotecan AE:

Back 31

Diarrhea and BMD

Front 32

Dactinomycin MOA

Back 32

Blocks DNA/RNA synthesis

Front 33

which 2 drugs are powerful iron chelators?

Back 33

Doxorubicin and Daunorubicin

Front 34

Uses of Daunorubicin

Back 34

ALL and ANLL

Front 35

Doxorubicin and Daunorubicin special toxicity

Back 35

Cardiotoxicity because of generation of free radicals.

Front 36

Bleomycin uses

Back 36

Lymphomas, squamous cell carcinomas, and head/neck cancers

Front 37

Bleomycin special toxicity

Back 37

Pulmonary toxicity that starts as pneumonitis and progresses to Pulmonary fibrosis

Front 38

L-Asparginase use

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Back 38

Standard agent for treating lymphocytic leukemias including ALL

Front 39

L-Asparginase adverse effects:

Back 39

Anaphylaxis, Coagulopathy, CNS effects, Thrombosis especially in the sagittal sinus, pancreatitis, glucose intolerance

Front 40

Prednisone MOA:

Back 40

suppress immune system

Front 41

Prednisone AE:

Back 41

cushing like syndromes, osteoporosis

Front 42

Tamoxifen MOA:

Back 42

non-steroidal anti-estrogen

Front 43

Tamoxifen Use:

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Back 43

Breast cancer
best results in ER+ tumors
also useful in osteoporosis b/c it increases bone mineralization

Front 44

Anastrozole MOA:

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Back 44

Competitively inhibit adrenal synthesis of steroids and inhibit conversion of androgens to estrogens. Use this drug when Tamoxifen isn't working

Front 45

Bortezomib Use

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Back 45

Multiple Myeloma

Front 46

Bortezomib MOA:

Back 46

inhibits proteosome

Front 47

Imatinib MOA

Back 47

inhibits Bcr-Abl tyrosine kinase

Front 48

Imatinib Use:

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Back 48

CML characterized by the Philadelphia chromosome

Front 49

Trastuzumab MOA

Back 49

monoclonal Ab to HER-2 receptor

Front 50

Trastuzumab use

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Back 50

aggressive ER(-) breast CA

Front 51

Bevacizumab MOA

Back 51

Blocks VEGF and cannot form vascular blood supply to tumor

Front 52

Bevacizumab uses:

Back 52

Metastatic colorectal CA

Front 53

Hydroxyurea MOA

Back 53

inhibits ribonucleotide reductase and inhibits DNA synthesis

Front 54

Hydroxyurea Uses

Back 54

melanoma, CML, ovarian CA