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22 Cards in this Set

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AMOXICILLIN(6 USES)
-UTIs (E.Coli and Proteus)
-Infectious Diarrhea(Salmonella)
-Otitis Media/Sinusitis(Haemophilus)
-Meningitis(Listeria)
-Endocarditis(Prevention)
-Peptic Ulcer(Helicobacter Pylori) w/ Clarithromycin and omeprazole
AMPICILLIN(7 USES)
-UTIs (E.Coli and Proteus)
-Infectious Diarrhea(Salmonella)
-Otitis Media/Sinusitis(Haemophilus)
-Meningitis(Listeria)
-Endocarditis(Prevention)
-Group B Steptococcal infections
-Dental procedures in patients with valve abnormalities
NAFCILLIN
-antistaphylococcal
-ineffective against infections with MRSA
-used against penicillinase-producing organisms
-Endocarditis
-Osteomyelitis(Staphylococci)
OXACILLIN
-antistaphylococcal
-ineffective against infections with MRSA
-used against penicillinase-producing organisms
-Endocarditis
-Osteomyelitis(Staphylococci)
PENICILLIN G(4 USES)
-Pharyngitis(Hemolytic Strep)
-Syphilis(Treponema Pallidum)
-Pneumonia(Pneumococcus, Streptococcus)
-Meningitis(Meningococcus, Pneumococcus)
-Anthrax(Bacillus anthracis)
-Bacteriodes(except fragilis)
-Clostridium
TICARCILLIN
-Nosocomial Infections(Pseudomonas)
-GRAM- RODS
-combined with aminoglycoside
-combined with clavulanic acid
PIPERACILLIN
-MORE ACTIVE AGAINST PSEUDOMONAS THAN TICARCILLIN
-Nosocomial Infections(Pseudomonas)
-GRAM- RODS
-combined with aminoglycoside
-combined with clavulanic acid
PENICILLIN V - What is its special use?
Can be administered orally due to its acid resistance
BENZATHINE PENICILLIN G
-IM Injection produces low blood levels for 3 weeks
-useful against very sensitive organisms(Treponema Pallidum Syphilis)
AMPICILLIN - Name a side effect
-nonallergic rash in patients with mononucleosis
PENICILLINS - What is their primary use?
BACTERICIDAL
-GRAM+ COCCI
-GRAM+ RODS
-GRAM- COCCI
-SPIROCHETES
PENICILLINS - Name 5 general characteristics?
-Cell wall synthesis inhibitor
-Beta-Lactam Ring
-Penicillinase Sensitivity
-Acid-labile
-hypersensitivity
PENICILLINS - Pharmokinetic Properties
ABSORPTION - can be destroyed by gastric acid
DISTRIBUTION - cannot be transported across not inflamed BBB
EXCRETION - unchanged in urine by tubular secretion
PENICILLINS - Pharmacodynamics
MOA
-bind to penicillin-binding proteins(PBPs)
-inhibit x-linking inside bacterial cell wall
-inhibit transpeptidase enzymes
PENICILLINS - Name 3 mechanisms of resistance
-inactivation by beta lactamases
-alteration of target PBPs
-permeability barrier which prevents drug penetration(GRAM- BACTERIA)
PENICILLINS - Name the common side effects(2)
-hypersensitivity
-hemolytic anemia
Name the penicillinase-resistant penicillins
Methicillin
Nafcillin
Dicloxacillin
Oxacillin
METHICILLIN - name a side effect
interstitial nephritis
AMINOPENICILLINS
AMPICILLIN
AMOXICILLIN
-wider spectrum
-combined with clavulanic acid which is a penicillinase inhibitor to enhance spectrum
AMINOPENICILLINS
AMPICILLIN
AMOXICILLIN
Name 3 side effects
-hypersensitivity
-ampicillin rash
-pseudomembranous colitis
CARBENICILLIN
-Nosocomial Infections(Pseudomonas)
-GRAM- RODS
-combined with aminoglycoside
-combined with clavulanic acid
WHAT ARE THE ANTI-PSEUDOMONAL PENICILLINS
TICARCILLIN
CARBENICILLIN
PIPERACILLIN