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22 Cards in this Set
- Front
- Back
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AMOXICILLIN(6 USES)
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-UTIs (E.Coli and Proteus)
-Infectious Diarrhea(Salmonella) -Otitis Media/Sinusitis(Haemophilus) -Meningitis(Listeria) -Endocarditis(Prevention) -Peptic Ulcer(Helicobacter Pylori) w/ Clarithromycin and omeprazole |
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AMPICILLIN(7 USES)
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-UTIs (E.Coli and Proteus)
-Infectious Diarrhea(Salmonella) -Otitis Media/Sinusitis(Haemophilus) -Meningitis(Listeria) -Endocarditis(Prevention) -Group B Steptococcal infections -Dental procedures in patients with valve abnormalities |
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NAFCILLIN
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-antistaphylococcal
-ineffective against infections with MRSA -used against penicillinase-producing organisms -Endocarditis -Osteomyelitis(Staphylococci) |
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OXACILLIN
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-antistaphylococcal
-ineffective against infections with MRSA -used against penicillinase-producing organisms -Endocarditis -Osteomyelitis(Staphylococci) |
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PENICILLIN G(4 USES)
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-Pharyngitis(Hemolytic Strep)
-Syphilis(Treponema Pallidum) -Pneumonia(Pneumococcus, Streptococcus) -Meningitis(Meningococcus, Pneumococcus) -Anthrax(Bacillus anthracis) -Bacteriodes(except fragilis) -Clostridium |
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TICARCILLIN
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-Nosocomial Infections(Pseudomonas)
-GRAM- RODS -combined with aminoglycoside -combined with clavulanic acid |
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PIPERACILLIN
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-MORE ACTIVE AGAINST PSEUDOMONAS THAN TICARCILLIN
-Nosocomial Infections(Pseudomonas) -GRAM- RODS -combined with aminoglycoside -combined with clavulanic acid |
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PENICILLIN V - What is its special use?
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Can be administered orally due to its acid resistance
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BENZATHINE PENICILLIN G
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-IM Injection produces low blood levels for 3 weeks
-useful against very sensitive organisms(Treponema Pallidum Syphilis) |
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AMPICILLIN - Name a side effect
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-nonallergic rash in patients with mononucleosis
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PENICILLINS - What is their primary use?
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BACTERICIDAL
-GRAM+ COCCI -GRAM+ RODS -GRAM- COCCI -SPIROCHETES |
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PENICILLINS - Name 5 general characteristics?
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-Cell wall synthesis inhibitor
-Beta-Lactam Ring -Penicillinase Sensitivity -Acid-labile -hypersensitivity |
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PENICILLINS - Pharmokinetic Properties
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ABSORPTION - can be destroyed by gastric acid
DISTRIBUTION - cannot be transported across not inflamed BBB EXCRETION - unchanged in urine by tubular secretion |
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PENICILLINS - Pharmacodynamics
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MOA
-bind to penicillin-binding proteins(PBPs) -inhibit x-linking inside bacterial cell wall -inhibit transpeptidase enzymes |
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PENICILLINS - Name 3 mechanisms of resistance
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-inactivation by beta lactamases
-alteration of target PBPs -permeability barrier which prevents drug penetration(GRAM- BACTERIA) |
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PENICILLINS - Name the common side effects(2)
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-hypersensitivity
-hemolytic anemia |
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Name the penicillinase-resistant penicillins
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Methicillin
Nafcillin Dicloxacillin Oxacillin |
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METHICILLIN - name a side effect
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interstitial nephritis
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AMINOPENICILLINS
AMPICILLIN AMOXICILLIN |
-wider spectrum
-combined with clavulanic acid which is a penicillinase inhibitor to enhance spectrum |
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AMINOPENICILLINS
AMPICILLIN AMOXICILLIN Name 3 side effects |
-hypersensitivity
-ampicillin rash -pseudomembranous colitis |
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CARBENICILLIN
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-Nosocomial Infections(Pseudomonas)
-GRAM- RODS -combined with aminoglycoside -combined with clavulanic acid |
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WHAT ARE THE ANTI-PSEUDOMONAL PENICILLINS
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TICARCILLIN
CARBENICILLIN PIPERACILLIN |
