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18 Cards in this Set

  • Front
  • Back
polymyxins, nystatin, amphotericin B
disrupt membrane integrity
aminoglycosides, streptomycin
inhibit protein synthesis by binding to a specific protein of 30S ribosomal subunit
aminoglycosides, gentamicin
bind to 30S ribosomal subunit at multiple sites. inhibit protein synthesis
block protein synthesis by inhibiting binding of amino-acyl t-RNA to 30S subunit
erythromycin, azithromycin, clindamycin, chloramphenicol
bind to 50S ribosomal subunit. inhibit protein synthesis at chain elongation step
oxazolidinones, linezolid
bind rRNA on both ribosomal subunits
streptogramins, dalfopristin, quinupristin
binds to 50S ribosomal subunit
binds isoleucyl tRNA synthetase, preventing charging of Ile-tRNA and thus affecting protein synthesis
fluoroquinolones, ciprofloxacin/moxifloxacin
inhibit bacterial DNA gyrase
nitroimidazoles, metronidazole
fragment DNA
binds to bacterial RNA polymerase and blocks transcription
azoles, fluconazole
inhibit ergosterol synthesis
ethambutol, pyrazinamide
unknown, anti-TB
inhibit synthesis of dihydrofolate
competitive inhibitor of dihydrofolate reductase. blocks synthesis of tetrahydrofolate
inhibits synthesis of mycolic acid (specific for Mycobacteria)
B-lactams, penicillins, cephalosporins
interfere with cell wall biosynthesis. inhibition of transpeptidation weakens cell wall. autolytic enzymes of bacteria then promote lysis
cycloserine, bactitracin, glycopeptides, vancomycin
interfere with cell wall biosynthesis