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8 Cards in this Set
- Front
- Back
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Sulfonamides |
MOA: Targets dehydropteroate sunthase (DHPS) and prevents addition of para-aminobenzoic acid (PABA, inhibiting folic acid synthesis 1) Target Modification |
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Rifampicins |
MOA: interacts with the beta-subunit of the bacterial RNA polymerase to block RNA synthesis 1) Target Modification |
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Tetracylines |
MOA: Target and bind to 30S ribosomal subunit to prevent aminoacyl-tRNA from attaching to RNA-ribosome complex, inhibiting protein synthesis 1) Reduced intercellular accumulation 2) target modification |
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Macrolides |
MOA: target and bind to 50S ribosomal subunit to inhibit translocation and transpeptidation process, resulting in inhibition of protein synthesis 1) Reduced intracellular uptake 2) Target Modification |
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Aminoglycosides |
MOA: Target and bind to the 30S ribosomal subunit to cause misreading of the genetic code which results in inhibition of protein synthesis 1) Antibiotic (Structural) modification 2) Target Modification 3) reduced uptake |
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Quinolones |
MOA: Targets DNA gyrase and topoisomerase IV of the bacteria and inhibits the necessary step of supercoiling 1) Target Modification 2) Reduced intracellular accumulation |
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Glycopeptides |
MOA: Inhibit the last stages of cell wall assembly by preventing cross-linking reactions 1) Target modification 2) Production of false targets |
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Beta-lactams |
MOA: target and bind to PBPs, inhibiting bacterial call wall synthesis 1) Enzymatic destruction of b-lactam rings 2) target (PBP) modification 3) Reduced Intracellular accumulation |
