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12 Cards in this Set
- Front
- Back
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Antibiotics that affect membrane permeability
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polymixins, polyenes, nystatin, amphotericin B
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inhibit protein synthesis by binding to a specific protein of 30S ribosomal subunit
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aminoglycosides: gentamicin, kanamycin, neomycin, amikacin, tobramycin
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Block protein synthesis by inhibiting binding of amino-acyl t-RNA to 30S subunit
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tetracyclines
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bind to 50S ribosomal subunit; inhibits protein synthesis at chain elongation step
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erythromycin, azithromycin, clindamycin, chloramphenicol
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bind rRNA on both ribosomal subunits (new)
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oxazolidinones, linezolid
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bind to 50S ribosomal subunit (new)
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streptogramins, dalfopristin, quinupristin
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Binds isoleucyl tRNA synthetase, preventing charging of Ile-tRNA and thus affecting protein synthesis
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Mupirocin
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Inhibits bacterial DNA gyrase
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Fluoroquinolones, ciprofloxacin
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Fragment DNA
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nitroimidazoles
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Binds to bacterial RNA polymerase and blocks transcription
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Rifampin
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Inhibit ergosterol synthesis
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Azoles, fluconazole
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Unknown mechanism, anti-TB
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ethambutol, pyrazinamide
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