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8 Cards in this Set
- Front
- Back
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antimicrobrials |
target bacterial/fungai cell wall synthesizing enzymes bacterial ribosomes DNA synthesis enzymes Viral replication targets |
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cell wall & membrane active antimicrobrials
beta lactams |
group of Abx contain beta lactam ring PCN cephalosporins monobactams carbapenems |
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Beta-lactam MOA |
inhibit bacterial growth-interferes with transpeptidation reaction of bacterial cell wall synthesis -bact. CW rigid outer layer unique to bacteria(surrounds Cytoplasmic membrane & protects cell- composed of peptidoglycan polymers linked by side chains pcn binding protein removes terminal alanine side chain-allowing cross linking -BL=structural analogues to this alanine chain ( mimic natural structure of bacterial wall, bind covalently to PCNbinding protein, renderin it useless
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methods of BL resistance BL & alter target pcn bind prtn |
BL- inactivate beta lactams alter target pcn-bind prtn- -low affinity for BL binding -mech for MRSA |
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BL resistance methods- Impaired drug peneatration efflux pumps |
IMpaired drug peneatration -down reg or alteration of porins -common for gram - bacteria Efflux pumps -force drugs out of cell |
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PCN |
all pcn share common core -variations in side chain determine properties of each drug -integrity of rings structure is essential for biologic activity of these drugs -common path of drug resist. in this class is BL enzymes -most stable in gastric acid (oral admin good) |
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PCN classes Traditional PCN (PEN V, Pen G) |
most active against gram + organisms, gram - cocci, and non beta lactamase producing anaerobes susceptible to hydrolysis by beta-lactamases |
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PCN class- Antistaphyloccocal PCN Dilcoxacillin, nafcillin, oxacillin |
active vs staphylococci & streptococci resist to staphyloccal beta-lactamases |
