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15 Cards in this Set

  • Front
  • Back
Carbapenem members and general spectrum
Imipenem, meropenem, doripenem, ertapenem
Broadest antibacterial spectrum of the B-lactam class
Are carbapenems B-lactamase stable?
Yes; however cases of resistance (carbapenemases) have occurred
Imi/mero/doripenem spectrum specific coverage (4)
S. aureus (MSSA)
Enterobacteriaceae (including ESBLs)
SPACE organisms
Anaerobes
Ertapenem spectrum specific coverage
Same except no activity against pseudomonas or acinetobacter
Clinical use of imi/mero/doripenem
Empiric therapy for polymicrobial, nosocomial, and suspected MDR infections
Does imipenem resistance predict mero/dori resistance?
Nope
What carbapenem is approved for meningitis?
Meropenem
What serious infections does ertapenem not cover?
Pseudomonas and acinetobacter
What is special about ertapenem's half life?
It's long and therefore allows for once daily dosing
Monobactam and route
Aztreonam
IV 1-2 g q6-8h
Aztreonam coverage
Gram negative activity only
Enterobacteriaceae
Some pseudomonas activity
What pathogens is Aztreonam intrinsically resistant to?
Burkholdera, Stenotrophomonas, and Acinetobacter spp.
Can Aztreonam be used in patients ith hypersensitivity to other B-lactams?
Yes
Is Aztreonam recommended for usage in combination with gram positive agents?
Aztreonam is effective when used in combination with gram positive agents
What happens when carbapenems are used with Gancyclovir or valproic acid?
Increased risk of seizures