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27 Cards in this Set
- Front
- Back
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What is MOA:
Which Organisms does it affect: PCN |
Disrupts Cell Wall
B-lactamase Most gram positive/some gram negative |
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What is MOA:
Which Organisms does it affect: Augmentin |
Bacteriacidal
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What is MOA:
Which Organisms does it affect: Cephalosporins |
B-Lactamase
less resistant than PCN |
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Which Organisms does it affect:
1st Generation Cephalosporins |
Many Gram Positive
some Gram Negative |
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Which Organisms does it affect:
2nd Generation Cephalosporins |
Even number Gram Positive and Gram Negative
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Which Organisms does it affect:
3rd Generation Cephalosporins |
Some Gram positive
Many Gram Negative |
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What is important about
Monobactams and Carbpenems |
they are very specialized with lots of side effects
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Which 3 Aminoglycosides should we know?
Do they affect Gram Negative or Positive? MOA: |
Gentamycin
Streptomycin Tobramycin EXCLUSIVELY Gram Negative Bactericidal |
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Which 3 Tetracyclines should we know?
Do they affect Gram Negative or Positive? MOA: |
Doxycycline
Mnocycline Tetracycline Even Gram + and Gram - Bacteriostatic by disrupting protein in the RNA translation |
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Which 3 Macrolides should we know?
Do they affect Gram Negative or Positive? MOA: |
Erythromycin
Clarithromycin Azithromycin Gram+ and Gram - Bactericidal and Bacteriostatic |
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What is the difference between bactericidal and bacteriostatic?
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Bacteriostatic freezes bacteria in time and then body has to kill off remainder of bacteria. Do not use if patient is immunocompromised
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which antibiotic disrupts cell reproduction?
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Sulfa - oldest antibiotic
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What is MOA:
Which Organisms does it affect: Sulfa |
Bacteriostatic - interferes with PABA and folic acid synthesis for cell division
Some gram + and some Gram - NO ANEROBES LOTS OF RESISTANCE |
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Which 3 Floroquinolones should we know?
What is MOA: Which Organisms does it affect: How does resistance occur: |
Cipro
Levaquin ofloxacin Bactericidal - DNA replication inhibitors Gram + and Gram - Resistance occurs by mutation |
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What is MOA:
Which Organisms does it affect: Vancomycin |
Tricyclic glycopeptide
Disrupt cell wall formation at the peptidoglycan strand formation Bactericidal - gram + (aerobic and anerobic organisms) |
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What is MOA:
Which Organisms does it affect: Nitrofurantoin |
Interferes with cell wall formation
Bacteriostatic broad spectrum with low resistance |
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What is MOA:
Which Organisms does it affect: Metronidazole |
MOA not fully known
Alters the DNA to prevent replication Works on C. Diff, anaerobes, parasites |
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What is most common parasite in world
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Malaria
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What is most common parasite in US
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Trich
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2nd most common parasite infection
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Protozoas- Giardia and Cryptosporidium
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3 ways antiparasitics work
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poison
starve paralyze |
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What makes a virus different?
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only 1 strand of RNA
invade every known cell type not alive |
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What is similar about a virus and a parasite?
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they rely on the host cell for protein synthesis and replication.
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Influenza treatment medications: (4)
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Amantidine
Rimantidine Tamiflu Relenza |
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How does amantidine and Rimantidine work?
**(Not really sure on this one) |
prevent virus from binding to cell so it can't transfer its RNA for replication
Virostatic |
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How do Tamiflu and Relenza work?
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Neuramidase inhibitors
break the bond holding virus to host cell Virostatic |
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how do retrovirals work?
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replicates backwards RNA to DNA (needs enzyme to do this – reverse transcriptase)
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