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9 Cards in this Set

  • Front
  • Back
plasmid-coded, trimethoprim-resistant dihydrofolate reductase
trimethoprim
hydrolysis of B-lactam ring by B-lactamase enzyme; decreased cephalosporin permeability of bacteria to the antibiotic
penicillin
(also, altered penicillin binding proteins)
altered penicillin binding proteins (not in B-lactamase)...a beta lactamase resistant penicillin
methicillin
enzymatic modification of drug by plasmid coded enzyme; decreased permeability of bacteria to the antibiotic; mutation alters site to which antibiotic normally binds (eg. S12 ribosomal protein for streptomycin)
aminoglycosides
interference with transport of drug into cell
tetracyclines
detoxification of drug by acetylation of hydroxyl
chloramphenicol
altered target enzymes (gyrase, RNAP)
ciprofloxacin, rifampin
enzymatic methylation of 23S ribosomal RNA
erythromycin
alteration of cell wall precursor target
vancomycin