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9 Cards in this Set
- Front
- Back
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plasmid-coded, trimethoprim-resistant dihydrofolate reductase
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trimethoprim
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hydrolysis of B-lactam ring by B-lactamase enzyme; decreased cephalosporin permeability of bacteria to the antibiotic
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penicillin
(also, altered penicillin binding proteins) |
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altered penicillin binding proteins (not in B-lactamase)...a beta lactamase resistant penicillin
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methicillin
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enzymatic modification of drug by plasmid coded enzyme; decreased permeability of bacteria to the antibiotic; mutation alters site to which antibiotic normally binds (eg. S12 ribosomal protein for streptomycin)
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aminoglycosides
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interference with transport of drug into cell
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tetracyclines
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detoxification of drug by acetylation of hydroxyl
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chloramphenicol
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altered target enzymes (gyrase, RNAP)
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ciprofloxacin, rifampin
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enzymatic methylation of 23S ribosomal RNA
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erythromycin
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alteration of cell wall precursor target
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vancomycin
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