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42 Cards in this Set

  • Front
  • Back
Protein Synthesis Inhibitors
Aminoglycosides
Tetrcycline

Chloarmphenicols, Clindamycin
Erythromycin (macrolides)
Lincomycin
Lonezolid

"Buy AT 30, CCELL at 50"

only aminoglycosides are cidal
Cell Wall Synthesis Inhibitors
B-lactams

Glycopeptides
Nucleic Acid Synthesis Inhibitors
Rifampin

Quinilones

"NA/RQ"
Folate Acid Metabolism Inhibitors
TMP-SMZ

FA/TS
Misc
metronidazole

lipopeptide

polymixins
Tetracycline: ex, moa, use
ex: doxycycline

binds 30s

used for borrelia, chlamydia, erchiliosis, ricketsia, anaplasmosis
Aminoglycosides: moa, use, ae
binds 30s, inhibiting the translocation of the peptidyl-tRNA from the A-site to the P-site and also causing misreading of mRNA (cidal)

used for aerobic, gram negatives and enterococci, will not work for anaerobes

so work for bowel prep for surgery or subacute endocarditis

nephrotoxic
ototoxic
teratogen
Chloramphenicols: moa, ae, use
old broad spectrum abx,

inhibits 50s peptidyltransferase

gray baby syndrome due to bone marrow anaplasia (infants lack liver udp-gluconronyl transferase)
Streptogramins: ex, moa, use
1st gen = qunitapristin
2nd gen = dalfopristin

binds 50s

used for MRSA, VRSA last resort
Glycycline: ex
tigecycline
macrolides: ex, moa, use
ezythromycin/azythromycin, azolides

bind 50s, blocking translocation. static

opthamia neonatorum (both gono and chlamydial)
Haemophilius
Bordetella
Legionella
Salmonella
Campylobacter
Helicobacter
Trephonemes
Mycoplasma

anything doxy can do also
Clindamycin moa, use
clindamycin

binds 50s, stops translocation

anaerobes
linezolide: moa, use, ae
binds 50s of initial A-site to tRNA binding preventing protein synthesis

mrsa, vrsa

leukopenia with prolonged use
B-lactams
monobactams
pcn
cephalosporins
carbapenemes
Monobactams
azetreonam

magic bullet for gram neg aerobics
uses of pcn
strep, spirochetes, clostridium
ampicillin
pcn plus nh3 group to make it better at getting into gram negative portins
amoxicillin
amp plus oh group to make it acid stable so it can be given po
pcn g vs v
g=iv

v= oral
moa of pcn
bind pcn-binding proteins which blocks transpeptidase cross linking of cell wall
ae's of pcn
hypersensitivity rxns

hemolytic anemia
methicillin/naficillin/dicloxacillin
penicillinase resitant pcns

used for s. aureus
uses of amoxicilin/ampicillin
HELPS with Enterococci

H=heamophilis
E= e.coli
L=l.mono
P=P.mirabilis
S=salonella
Enterococci
treament of VRSA
streptogramins and linezolid
Vancomycin: moa, use
binds d-ala-d-ala

only good for gram + b/c too big for pores of gram -
Rifamycin: moa, use, ae's
inhibit dna-dept RNA polymerase (block mRNA synthesis)

prophylaxis for N. meningitides, H. influenzae
TB

minor hepatoxic
increased p450
red organge body fluids

Ramps up P450
Red/Orange Fluids
Rapid resistance if used alone
RNA polymerase inhibitor

"4 R's"
Fluoroquinilones; moa, use, ae
"floxacins"

inhibit dna gyrase/topo II (cidal)

gram neg for UTI and GI infections and some gram positive

quiniLONES attach to BONES. damage to cartilage (in utero), tendonitis/tendon rupture , leg cramps, myalgias
TMP-SMX moa, use
tmp=block DHF->THF (blocks DHF reductase)
smx=block PABA->DHP (blocks DHP synthase)

pathway goes: PABA->DHP->DHF->THF->cofactors needed for nucleic acid synthesis

board spectrum (not enterococci)
metronidazole: moa, use, ae
creates free radicals

GET GAP

Giardia
Entamoeba
Trichomonas
Gardneralla
Anaerobes (bacteriodes, clostridium)
Pylori

disulfiram effect
Daptomycin: moa, uses
creates pores

resistant gram+ (like staph or enterococci)

NOT good for pneumonia cuz cant get into lungs
Polymixins: moa, uses, ae
detergent like action

resistant gram negative

neurotoxic, acute renal tubular necrosis
Uses of PCN
gram + rods
gram + cocci
gram - cocci
spirochetes
AEs of PCN
hypersensitivity rxn

hemolytic anemia
Uses of Ampicillin/Amoxicillin?
H. influenza
E. coli
L. mono
P. mirabilis
Salmonella
Entercocci

"HELPS with Enterococci"
Why is methicillin/naficillin/dicloxacillin better than PCN?
penicillinase-resistant

bulkier R group
Uses of Cephalosporins?
1st gen = gram + cocci, P. mirabilis, E. coli, Klebsiella

2nd gen=H. influenza, Enterobacter, Neisseria, Seratia

3rd gen= more stuff

4th gen=pseudomonanas and more stuff

"HENS PEcK"
Aztreonam
monobactam

resistant to B-lactamases

only good for gram - rods
TB regimen
isoniazid
streptomycin (aminoglycoside)
pyrazinamide
rifampin
ethambutol

"spire"
VRE treatment
streptogramin

linezolid
abx to avoid during pregnancy
sulfas-kerinecturs
aminoglycosides-nephrotoxic, ototoxic, teratogen
fluorogunilones-cartilage damage
erythromycin- acute cholestatic hepatitis in mom
metronidazole-teratogen
tetracycline-teeth/bone problems
chloramphenicol-'gray baby'

"SAFE Moms Take Good Care"
ethambutol: moa, use, ae
anti TB

inhibits carb polymerization preventing cell wall synthesis

causes visual problems, red-green color blindness
Isoniazid: moa, use, ae
anti TB or prophylaxis for TB

decreases synthesis of mycolic acids

hemolysis if g6pd def, hepatoxic, neurotoxic, ototoxic, sle

pyridoxine can prevent neurotoxicity