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5 Cards in this Set

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Why is the cell wall essential for (most) bacteria and hence a good target for many antibiotics?
Cell wall prevents bacteria from lysing as water enters from the external environment.
Thus, if you block cell wall synthesis in dividing bacteria, they will explode b/c the salt concentration is so much higher in them than in the external environment.
IV, IM, (oral)
Poorly absorbed orally.

G+/G- cocci
NOT vs G- rods and anaerobes.

Beta lactamase sensitive

Pneumococcus
Non-lactamase Staphylococcus
Neisseria meningitidis
Clostridium
Treponema pallidum
Penicillin G
Orally available version of Penicillin G!
-Note: Oral route NOT good for serious infections.
Penicillin V
Penicillins (Beta lactams) that are resistant to beta lactamases and prescribed primarily for Staphylococcus aureus b/c it produces penicillinases!! (4)
Oxacillin, Nafcillin, Methicillin, Cloxacillin
What are the 2 key “extended spectrum” beta lactams?
Amoxacillin, Piperacillin