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27 Cards in this Set
- Front
- Back
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Ampicillin
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G+ and G- penicillin
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Carbenicillin
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G+ and G- penicillin
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Cephalosporin
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Cafepime, G- and G+ B lactam
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Carbapenems
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Imipenem and meropenem, G- and G+, B-lactam
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Monobactam
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aztreonam, G-, aerobic rods, B-lactam
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Vancomycin
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Glycopeptides, G+, binds directly to D-Ala-D-Ala portion of cell wall
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Cycloserine
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G-, structural analog of D-Ala- inhibits its incorporation
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Bacitracin
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G+, interferes with recylcing of bactoprenol
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Polymixin
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G-, disrupts cell membrane and makes more permeable so water uptake leads to cell death
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Daptomycin
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G+, binds to cell membrane and induces rapid depolarization of membrane potential
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Rifamycin
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Binds B subunit of bacterial RNA polymerase
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Quinolones
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Nalidixic acid, G-, impair gyrase
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Flouroquinolones
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Cipro, G+, G-, gyrase
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Metronidazole
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cytotoxic intermediates interact with host cell DNA
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Aminoglycosides
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tobramycin, gentamicin, amakacin, bind 30S to block translation elongation
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Tetracyclines
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bind 30S, blocks AA-tRNA binding
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Chloramphenicol
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bind 50S, blocks peptidyl transferase
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Macrolides
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erythromycin, binds 50S and prevents translocation
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Lincosamides
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G+, binds 50S to prevent translocation
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Streptogramins
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synercid, binds 50S to cause release of growing peptide
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Oxazolidinones
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Zyvox, G+, Binds 50S to prevent it from binding 30S and initiator met tRNA
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Sulfonamides
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G+ and G-, analogues of PABA- cannot form THF- no folic acid
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Isoniazid
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Blocks fatty acid synthase thereby blocking mycolic acid production- used for TB
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Ethambutol
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blocks polymerization of carbohydrates in mycobacterium cell wall- used in TB
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Pyrazinamide
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Blocks fatty acid synthase thereby blocking mycolic acid production- used for TB
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Amphotericin B
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binds to ergosterol and causes direct damage to cell membrane- used for Fungi
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Fluconazole, Imidazole, and Itraconazole
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inhibits conversion of Ianosterol to ergosterol- disrupts membrane synthesis in fungi
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