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41 Cards in this Set

  • Front
  • Back

What is the mechanism behind Class I?

Na+ channel blockers

What are the Class IA drugs?

Quinidine, Procainamide, Disopyramide

What Class IA is for ventricular arrythmias only?

Disopyramide

Which Class has a medium decrease of phase 0 slope, increased ERP, increased AP duration (risk of torsades), and a medium duration off rate?

Class IA

What are the Class IB drugs?

Lidocaine, Mexilitine

Which Class has a small decrease of phase 0 slope, may decrease ERP, may decrease AP duration, a short duration off rate, and preferentially interacts w/ inactivated Na channels (and is thus rate dependent)?

Class IB

Which drug can cause seizures if administered too rapidly?

Lidocaine

Which Class is used for ventricular arrythmias only?

Class IB

Which Class is best post-MI?

Class IB

Which Class IB drug is orally effective?

Mexilitine

Which Class has a pronounced decrease of phase 0 slope, slow conduction, little effect on ERP and APD, and a long duration off rate?

Class IC

What are the Class IC drugs?

Flecainide, Propafenone

Which class is used for SVTs, including A fib?

Class IC

Which class is contraindicated in structural and ischemic heart disease?

Class IC

What is the mechanism of Class II drugs?

sympatholytic agents (B-adrenergic receptor blockade)

What are the class II drugs?

Propranolol, metoprolol, esmolol, atenolol, timolol, carvedilol

How do Class II drugs decrease SA and AV nodal activity?

decrease cAMP and Ca2+ currents

How do Class II drugs suppress abnormal pacemakers?

decrease slope of phase 4

Which drug is a B-blocker and Na channel blocker?

propranolol

What are the clinical uses of Class II drugs?

SVT, slow ventricular rate during A fib and A flutter, slows SA node and ectopic pacemakers

Which drug is contraindicated is asthmatics because it can cause bronchospasm?

propranolol

What is the mechanism of Class III drugs?

K+ channel blockers (prolong repolarization--proarrythmic)

What are the Class III drugs?

Amiodarone, Ibutilide, Dofetilide, Sotalol

Which Class increases ERP, increases APD, and increases QT interval?

Class III

Which drug blocks Na+, Ca2+, B-adrenoreceoptors, and K+ channels?

Amiodarone

Which drug is a non-selective hERG blocker (and therefore doesn't cause EADs)?

Amiodarone

Which drug is for unstable VT, VF, and SVT?

amiodarone

Which drug causes pulmonary toxicity, liver disease, and hypothyroidism in some patients, and corneal deposits in all patients?

Amiodarone

Which drug can be used for VT, A fib, and A flutter, but can cause torsades?

sotalol

Which drug can cause immediate conversion of A fib or flutter to sinus rhythm, but causes torsades in ~6%?

Ibutilide

Which drug is an IKR blocker and has a high risk of torsades?

Dofetilide

What is the mechanism of Class IV drugs?

Ca2+ channel blockers

Which Class slows conduction velocity, increases ERP, and increases PR interval?

Class IV

What are the Class IV drugs?

Verapamil, diltiazem

What drug blocks Na+ in addition to Ca++ channels and slows the SA node in tachycardia?

Verapamil

Which drugs reduces automaticity, decreases the conduction velocity of the AV node, and inhibits contractility?

Verapamil and diltiazem

Which drugs are used to prevent nodal arrythmias (SVTs) and for rate control in atrial fibrillation?

Verapamil and diltiazem

Which drug increases K+ out of cells, hyperpolarizing the cell and decreasing ICa?

Adenosine

Which drug is the drug of choice in diagnosing/abolishing SVT and is very short acting (~15 sec)?

Adenosine

Which drugs effects are blocked by theophylline and caffeine?

Adenosine

Which drug is effective in torsades de pointes and digoxin toxicity?

Mg++