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41 Cards in this Set
- Front
- Back
What is the mechanism behind Class I? |
Na+ channel blockers |
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What are the Class IA drugs? |
Quinidine, Procainamide, Disopyramide |
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What Class IA is for ventricular arrythmias only? |
Disopyramide |
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Which Class has a medium decrease of phase 0 slope, increased ERP, increased AP duration (risk of torsades), and a medium duration off rate? |
Class IA |
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What are the Class IB drugs? |
Lidocaine, Mexilitine |
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Which Class has a small decrease of phase 0 slope, may decrease ERP, may decrease AP duration, a short duration off rate, and preferentially interacts w/ inactivated Na channels (and is thus rate dependent)? |
Class IB |
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Which drug can cause seizures if administered too rapidly? |
Lidocaine |
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Which Class is used for ventricular arrythmias only? |
Class IB |
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Which Class is best post-MI? |
Class IB |
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Which Class IB drug is orally effective? |
Mexilitine |
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Which Class has a pronounced decrease of phase 0 slope, slow conduction, little effect on ERP and APD, and a long duration off rate? |
Class IC |
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What are the Class IC drugs? |
Flecainide, Propafenone |
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Which class is used for SVTs, including A fib? |
Class IC |
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Which class is contraindicated in structural and ischemic heart disease? |
Class IC |
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What is the mechanism of Class II drugs? |
sympatholytic agents (B-adrenergic receptor blockade) |
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What are the class II drugs? |
Propranolol, metoprolol, esmolol, atenolol, timolol, carvedilol |
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How do Class II drugs decrease SA and AV nodal activity? |
decrease cAMP and Ca2+ currents |
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How do Class II drugs suppress abnormal pacemakers? |
decrease slope of phase 4 |
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Which drug is a B-blocker and Na channel blocker? |
propranolol |
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What are the clinical uses of Class II drugs? |
SVT, slow ventricular rate during A fib and A flutter, slows SA node and ectopic pacemakers |
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Which drug is contraindicated is asthmatics because it can cause bronchospasm? |
propranolol |
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What is the mechanism of Class III drugs? |
K+ channel blockers (prolong repolarization--proarrythmic) |
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What are the Class III drugs? |
Amiodarone, Ibutilide, Dofetilide, Sotalol |
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Which Class increases ERP, increases APD, and increases QT interval? |
Class III |
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Which drug blocks Na+, Ca2+, B-adrenoreceoptors, and K+ channels? |
Amiodarone |
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Which drug is a non-selective hERG blocker (and therefore doesn't cause EADs)? |
Amiodarone |
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Which drug is for unstable VT, VF, and SVT? |
amiodarone |
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Which drug causes pulmonary toxicity, liver disease, and hypothyroidism in some patients, and corneal deposits in all patients? |
Amiodarone |
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Which drug can be used for VT, A fib, and A flutter, but can cause torsades? |
sotalol |
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Which drug can cause immediate conversion of A fib or flutter to sinus rhythm, but causes torsades in ~6%? |
Ibutilide |
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Which drug is an IKR blocker and has a high risk of torsades? |
Dofetilide |
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What is the mechanism of Class IV drugs? |
Ca2+ channel blockers |
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Which Class slows conduction velocity, increases ERP, and increases PR interval? |
Class IV |
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What are the Class IV drugs? |
Verapamil, diltiazem |
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What drug blocks Na+ in addition to Ca++ channels and slows the SA node in tachycardia? |
Verapamil |
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Which drugs reduces automaticity, decreases the conduction velocity of the AV node, and inhibits contractility? |
Verapamil and diltiazem |
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Which drugs are used to prevent nodal arrythmias (SVTs) and for rate control in atrial fibrillation? |
Verapamil and diltiazem |
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Which drug increases K+ out of cells, hyperpolarizing the cell and decreasing ICa? |
Adenosine |
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Which drug is the drug of choice in diagnosing/abolishing SVT and is very short acting (~15 sec)? |
Adenosine |
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Which drugs effects are blocked by theophylline and caffeine? |
Adenosine |
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Which drug is effective in torsades de pointes and digoxin toxicity? |
Mg++ |