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57 Cards in this Set
- Front
- Back
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Class IA antiarrythmics
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Quinidine
Pracainamide Disopyramide |
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Class IA drugs action on which parts of the heart
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Artia and Ventricle
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this class of antiarrythmics lengthens the AP and QT interval
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Class IA
Quinidine Pracainamide Disopyramide |
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Class IB antiarrythmics
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Lidocaine
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Part of heart that Class IB drugs acts on
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ventricles only
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Drugs IA effect on action potential
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lengthens (see long QT)
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Drugs IB effect on action potential
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shortens
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Drugs IC effect on action potential
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no effect
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A long QT interval is the effect of what class of antiarrythmics
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Class IA
Quinidine Procainamide Disopyramide |
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Class IC antiarrythmics
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Flecainide
Propafenone |
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Use of Group IA drugs
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all arrhytmias, esp chronic outpatients
Quinidine Pracainamide Disopyramide |
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Side effects of Quinidine
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cinchonism (headache, ringing)
cardiac depression GI distress allergic thrombocytopenic purpura |
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causes cinconism and thrombocytopenic purpura
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Quinidine
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quinidine drug interactions
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Reduces clearance of digoxin and glycosides
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Toxicity of procainamide
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reversible SLE likes symptoms
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Your patients new antiarrhytmic is causing her to have lupus like symptoms. What drug is she on
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Procainamide (IA)
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Disopyramide has what side effect?
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Antimuscarinic leading to CHF
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What ion may effect the efficacy of group I antiarrhytmics
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kyperkalemia exacerabtes cardiac toxicity of Group I drugs
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Use of Lidocaine
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acute ventricular arrhythmias
esp after MI |
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Lidocain is ineffective against atrial arrhythmias unless they are caused by what?
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digitalis
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method of delivery for lidocaine
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IV
IM possible |
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side effects of lidocaine
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CNS stimulation
convulsion cardiac depression allergic rash -->anaphylaxis |
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where group IC drugs act
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artia and ventricles
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what group IC antiarrhytmics are approved for?
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refractory ventricular tachycardias
intractable supraventricular arrhytmias |
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this group of antiarryhtmics is approved only for regractory ventricular tachycardias
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group IC
flecainide propafenone |
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of the group I antiarrhytmics, this one is more likely to precipitate arrhytmias
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group IC
flecainide propafenone |
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Group II antiarrhytmics
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Propranolol
Acebutolol Esmolol |
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Method of action for group II antiarrhytmics
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cardiac beta block
lowers cAMP, lowers Na and Ca currents and suppress abnormal pacemakers |
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region of the heart particularly sensitive to group II antiarrhytmics
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AV node
Propranolol Acebutolol Esmolol |
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ECG findings w/ group II
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long PR
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your patient on antiarrhythmics has a lengthened PR interval. what is it?
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group II
propranolol acebutolol esmolol |
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short acting antiarrhytmic used exclusively for acute surgical arrhythmias
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esmolol
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use for propranolol and acebutolol
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prophylactic anti-a's for patients post MI
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Toxicity of group II anti-a
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heart failure
bronchospasm Na and water retention sensitization to hypoglycemia |
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Group III antiarrythmics
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K channel blockers
Amiodarone Sotalol Dofelitide Ibutilide |
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This group III drug also block sodium channels and lengtens AP
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Amiodarone
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This group III is a chiral compound where one isomer is a beta blocker and one is K channel blocker
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Sotalol
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ECG finding associated with group III drugs
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long QT from long AP
blocked K slows repolarization |
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Toxicity of sotalol
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tosade de pointes
excessive beta block (sinus brady and ashtma) |
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Recommedation for ibutilide
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atrial flutter and fib
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use for amiodarone
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any arrythmia, but only after other drugs have failed due to side effects
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side effects of amiodarone
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thyroid dysfuntion
paresthesias tremor microcrystalline deposites in cornea and skin pulmonary fibrosis |
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your arrhytmia patient develops pulmonary fibrosis and crystal deposites in his cornea. you should take him off of?
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Amiodarone
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This group III drug is an exception in that it rarely causes new arrhytmias
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Amiodarone
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dofelitide
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Class III
To convert and prevent Afib, Aflutter |
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Group IV anti-a's
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Ca channel blockers
verapamil diltiazem |
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Group IV effects on ECG
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long PR
acts on AV node |
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use for group IV anti-a
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prevention of nodal arrhytmias
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toxicity of verapamil and diltiazem
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excessive cardiac depression
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dose of adenosine needed for antiarrhytmic property
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6-12 mg IV
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effect of adenosine
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slows AV conduction markedly
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duration of action for adenosine
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15 seconds
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method of action for adenosine
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hyperpolarizes AV nodes and reduces Ca current
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list all drugs that prolong PR interval
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Group II (propranolo, acebultolol, esmolol)
Group IV (verapamil, diltiazem) Adenosine |
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Use of digitalis
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slows heart rate, slows AV conduction and protects ventricle from atrial flutter or fib
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theophylline antagonizes the effects of this anti-a
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adenosine
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adenosine should never be given to...
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asthmatics
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