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57 Cards in this Set

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Class IA antiarrythmics
Quinidine
Pracainamide
Disopyramide
Class IA drugs action on which parts of the heart
Artia and Ventricle
this class of antiarrythmics lengthens the AP and QT interval
Class IA

Quinidine
Pracainamide
Disopyramide
Class IB antiarrythmics
Lidocaine
Part of heart that Class IB drugs acts on
ventricles only
Drugs IA effect on action potential
lengthens (see long QT)
Drugs IB effect on action potential
shortens
Drugs IC effect on action potential
no effect
A long QT interval is the effect of what class of antiarrythmics
Class IA

Quinidine
Procainamide
Disopyramide
Class IC antiarrythmics
Flecainide
Propafenone
Use of Group IA drugs
all arrhytmias, esp chronic outpatients

Quinidine
Pracainamide
Disopyramide
Side effects of Quinidine
cinchonism (headache, ringing)
cardiac depression
GI distress
allergic thrombocytopenic purpura
causes cinconism and thrombocytopenic purpura
Quinidine
quinidine drug interactions
Reduces clearance of digoxin and glycosides
Toxicity of procainamide
reversible SLE likes symptoms
Your patients new antiarrhytmic is causing her to have lupus like symptoms. What drug is she on
Procainamide (IA)
Disopyramide has what side effect?
Antimuscarinic leading to CHF
What ion may effect the efficacy of group I antiarrhytmics
kyperkalemia exacerabtes cardiac toxicity of Group I drugs
Use of Lidocaine
acute ventricular arrhythmias
esp after MI
Lidocain is ineffective against atrial arrhythmias unless they are caused by what?
digitalis
method of delivery for lidocaine
IV

IM possible
side effects of lidocaine
CNS stimulation
convulsion
cardiac depression
allergic rash -->anaphylaxis
where group IC drugs act
artia and ventricles
what group IC antiarrhytmics are approved for?
refractory ventricular tachycardias
intractable supraventricular arrhytmias
this group of antiarryhtmics is approved only for regractory ventricular tachycardias
group IC

flecainide
propafenone
of the group I antiarrhytmics, this one is more likely to precipitate arrhytmias
group IC

flecainide
propafenone
Group II antiarrhytmics
Propranolol
Acebutolol
Esmolol
Method of action for group II antiarrhytmics
cardiac beta block

lowers cAMP, lowers Na and Ca currents and suppress abnormal pacemakers
region of the heart particularly sensitive to group II antiarrhytmics
AV node

Propranolol
Acebutolol
Esmolol
ECG findings w/ group II
long PR
your patient on antiarrhythmics has a lengthened PR interval. what is it?
group II

propranolol
acebutolol
esmolol
short acting antiarrhytmic used exclusively for acute surgical arrhythmias
esmolol
use for propranolol and acebutolol
prophylactic anti-a's for patients post MI
Toxicity of group II anti-a
heart failure
bronchospasm
Na and water retention
sensitization to hypoglycemia
Group III antiarrythmics
K channel blockers

Amiodarone
Sotalol
Dofelitide
Ibutilide
This group III drug also block sodium channels and lengtens AP
Amiodarone
This group III is a chiral compound where one isomer is a beta blocker and one is K channel blocker
Sotalol
ECG finding associated with group III drugs
long QT from long AP

blocked K slows repolarization
Toxicity of sotalol
tosade de pointes
excessive beta block (sinus brady and ashtma)
Recommedation for ibutilide
atrial flutter and fib
use for amiodarone
any arrythmia, but only after other drugs have failed due to side effects
side effects of amiodarone
thyroid dysfuntion
paresthesias
tremor
microcrystalline deposites in cornea and skin
pulmonary fibrosis
your arrhytmia patient develops pulmonary fibrosis and crystal deposites in his cornea. you should take him off of?
Amiodarone
This group III drug is an exception in that it rarely causes new arrhytmias
Amiodarone
dofelitide
Class III

To convert and prevent Afib, Aflutter
Group IV anti-a's
Ca channel blockers

verapamil
diltiazem
Group IV effects on ECG
long PR

acts on AV node
use for group IV anti-a
prevention of nodal arrhytmias
toxicity of verapamil and diltiazem
excessive cardiac depression
dose of adenosine needed for antiarrhytmic property
6-12 mg IV
effect of adenosine
slows AV conduction markedly
duration of action for adenosine
15 seconds
method of action for adenosine
hyperpolarizes AV nodes and reduces Ca current
list all drugs that prolong PR interval
Group II (propranolo, acebultolol, esmolol)
Group IV (verapamil, diltiazem)
Adenosine
Use of digitalis
slows heart rate, slows AV conduction and protects ventricle from atrial flutter or fib
theophylline antagonizes the effects of this anti-a
adenosine
adenosine should never be given to...
asthmatics