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50 Cards in this Set
- Front
- Back
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Class 1a (3 agents)
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Quinidine
Procainamide Disopyramide |
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Class 1b (2 agents)
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Lidocaine
Mexilitine |
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Class 1c (2 agents)
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Flecainide
Propafenone |
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Class 2 (Class of agents)
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Beta-blockers
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Class 3 (5 agents)
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**SADDI**
Sotalol Amiodarone Dronedarone Dofetilide Ibutilide |
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Class 4 (2 agents)
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Non-DHP CCBs (Verapamil and Diltiazem)
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4 electrolyte imbalances that may cause arrhythmia?
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K, Mg, Na, Ca
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Na entering cell?
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Depolarization
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Ca entering cell?
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Initiation of contraction
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K leaving cell?
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Repolarization
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__________ are early, extra beats that originate in atria and do NOT require therapy?
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Premature atrial contractions
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__________ is a marker for V-tach, including Torsades
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Prolonged QT interval
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What 2 classes of antiarrhythmics can prolong QT interval?
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Ia and III
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2 classes of ABX that are most likely to prolong QT?
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Macrolides
Quinolones |
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3 drugs or classes used for rate control in a-fib
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Beta-blockers
Non-DHP CCBs Digoxin |
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Which class 1a drug has active metabolites that are renally cleared?
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Procainamide
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Which class 1a drug must be taken with food?
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Quinidine
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Which class 1a drug has a BBW? (what is it for?)
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Procainamide- fatal blood dyscrasias and Lupus
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Which antiarrhythmic can cause cinchonism?
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Quinidine
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Which 1a drug has highest incidence of GI side effects?
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Quinidine
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Which 1a drug has anticholinergic activity?
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Disopyramide
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Which class 1b drug is IV? Which is PO?
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Lidocaine- IV
Mexilitine- PO |
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Both class 1b drugs need reductions in ________ impairment
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Liver
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BBW for class 1c drugs?
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Pro-arrhythmic effects
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Class 1c drugs are major substrates of?
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2D6
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2 most common drugs included as class 2 antiarrhythmics? (selectivity)
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Propranolol (non-selective), esmolol (B-1 selective)
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Amiodarone
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Pacerone, Cordarone
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Dronedarone
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Multaq
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Sotalol
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Betapace
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Ibutilide
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Corvert
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Dofetilide
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Tikosyn
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Which class III drug has 4 BBW, half-life of 50 days, is pregnancy D, and has a max dose of 100-400 mg/day?
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Amiodarone
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4 BBW for amiodarone?
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1.) initiate therapy in hospital
2.) lung damage 3.) liver toxicity 4.) exacerbation of arrhythmias |
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4 common/important side effects of amiodarone?
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1.) Hypo/hyper-thyroidism
2.) Corneal microdeposits 3.) Photosensivity 4.) Blue skin discoloration |
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Dosing for Multaq?
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400 mg PO BID with meals
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Dronedarone BBW?
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Heart Failure exacerbation
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Dronedarone is pregnancy category?
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X
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Which class III antiarrhythmic has highest risk of causing hepatic failure?
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Dronedarone (Multaq)
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Betapace vs Betapace AF?
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NOT INTERCHANGEABLE
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BBW for sotalol?
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-Initiation and dose changes must take place in hospital
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Sotalol is C/I if QT is > ?
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450
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What is the only class III agent available as IV?
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Ibutilide (Corvert)
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Which class III agent has a REMS?
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Dofetilide (Tikosyn)--> TIPS
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BBW for dofetilide
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Must be started/adjusted in hospital with 12+ hours cardiac monitoring
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Antiarrhythmic of choice in a patient with Asthma/COPD?
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Diltiazem or Verapamil
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How does adenosine work?
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Decreases conduction through AV node, restoring normal sinus rhythm
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Adenosine dosing
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6mg IV push (may increase to 12mg if needed)
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T1/2 of adenosine?
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less than 10 seconds
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Therapeutic range for digoxin in A-FIB
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0.8-2 ng/mL
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Indication for use of Adenocard?
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PSVT (NOT for A-fib, A-flutter, or V-tach)
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