Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
18 Cards in this Set
- Front
- Back
|
Quinidine
|
Class 1 A, slower acting, also blocks K channels (incr refractory period) also has anticholinergic action: increase AV conduction
|
|
|
Lidocaine
|
Class 1 B, selective, rapid, quickly dissociates, parenteral, no K blockage
also a short amide anesthetic |
|
|
Flecainide
|
Class 1 C, same as 1B only sloer acting
|
|
|
overall effects of Class 1 drugs
|
1.decrease excitability
2. slow rate of conduction |
|
|
Ibutilide
|
Class 3
1. Prolongs action potential (no repol) 2. cells remain in refractory period |
|
|
amiodarone
|
Class 3
1. Prolongs action potential (no repol) 2. cells remain in refractory period mixed action of all classes alters lipid membrane |
|
|
Sotalol
|
Class 3
1. Prolongs action potential (no repol) 2. cells remain in refractory period mixed action of class 2 and 3 |
|
|
esmolol
|
class 2 (BB)
1. decrease hr 2. decrease conduction...incr refractory period 3. decrease force of contractions |
|
|
propanolol
|
class 2 (BB)
1. decrease hr 2. decrease conduction...incr refractory period 3. decrease force of contractions |
|
|
verapamil
|
class 4 (CCB)
1. decrease hr 2. decrease conduction...incr refractory period 3. decrease force of contractions |
|
|
altered automaticity
|
class 1 and 2
|
|
|
increase HR
|
class 2 and 4
***delayed after depolarizations*** |
|
|
re-entry
|
Class 1 (selectively reduces retrograde conduction) and 3 (keeps it in refractory)
|
|
|
Class I action
|
blocks fast Na voltage dependent channels
|
|
|
Class 3 action
|
blocks K channels to increase refractory period
|
|
|
torsades de pointes causes:
|
impaired K channel function
1. genetic mutations 2. hypokalemia 3. class 1A quinidine 4. class 3 ibutilide and amiodarone ***early afterdepolarizations*** |
|
|
supraventricular arrhythmia tx:
|
***give sedative***
1. anticoagulant before starting antiarrhytmic 2. low AV conduction w/ BB or CCB, adenosine, digioxin 3. cardiovert w/ defib or class 1 or 3 maintain on class 1 or 3 or AV conduction blockers or ablation or pacemaker? |
|
|
Vtach Fib
|
defib or lidocaine (1B)
long term: class 1 or 3 |
