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10 Cards in this Set
- Front
- Back
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Amantadine/Rimantidine
Remember the "A's" |
MOA= blocks viral uncoating --> prevents penetration
(a man to dine must take of his coat) Also will cause Dopamine Release Use= Prophylaxis and treeatment for Influenza A Useful if can't get vaccine Trt of Parkinsons Toxic= Ataxia, Dizziness, Slurred Speech |
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Zanamivir/Oseltamivir
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MOA= Blocks neuraminidase to prevent virion release
Use= Influenza A and B infxn to shorten duration |
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Ribavirin
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MOA= inhibits synthesis of Guanine
Uses= RSV, Hep C Toxic= Hemolytic Anemia, Teratogen |
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Acyclovir
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MOA= Inhibits DNA Polymerase when phosphorylated by viral thymidine kinase
Uses= Herpes, EBV Toxic= Delerium, neurotoxic |
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Ganciclovir
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MOA= inhibits CMV DNA polymerase
Use= CMV in AIDS pts Toxic= Pancytopenia, renal toxicity |
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Foscarnet
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MOA= Inhibits Viral DNA poly and is not activated by phosphorylation
Use= CMV retinitis, acyclovir resistant Herpes Toxic= Nephro |
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Protease Inhibitors in HIV
all end in -navir |
MOA= inhibit new virus formation by preventing protease from cleaving genome
Toxicity= Hyperglycemia, Lipid Abnormalities, Thrombocytopenia |
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Nucleoside RTI's
-AZT, Didanosine, Lamivudine Non-Nucleoside RTI's -Nevirapine, Delaviridine, Efavirenz |
MOA= inhibit RTase of HIV to prevent incorporation into host genome
Toxic= Bone Marrow Suppression (esp AZT), Lactic Acidosis (nucleosides), Rash (non-nucleosides), Megaloblastic Anemia (AZT), Pancreatitis (Didanosine) |
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HIV HAART and Pregnancy Prophylaxis
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Combine use of NNRTI/NRTI along with Protease Inhibitor for HIV
AZT used in pregnancy to prevent transmission |
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Interferons
alpha Beta Gamma |
MOA= block viral DNA/RNA synthesis
Alpha- Chronic Hep B and C Beta- Multiple Sclerosis Gamma- NADPH oxidase deficiency Toxic= Neutropenia |
