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15 Cards in this Set
- Front
- Back
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Influenza anti virals
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Amantadine
Rimantadine Oseltamivir Zanamivir |
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Amantadine
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Influenza A
Toxicity: CNS effects Action: -inhibit early step of viral replication -locus of action Inf. A M2 receptor |
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Rimantadine
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same as amantadine.
Metabolized quicker, so less toxic effects |
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Oseltamivir
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inhibitor of viral neuraminidase
-enzyme necessary for release from cell. Side fx: mild nausea, abdominal discomfort |
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Zanamivir
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same as oseltamivir
inhalation |
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Broad Spectrum Antiviral
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Ribavirin
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Ribavirin
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Inhibits wide range of RNA and DNA viruses.
-viral pneumonia and bronchiolitis cause by respiratory syncitial virus(aerosol) -Lassa and Hanta virus (IV) |
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Anti-Herpes Simplex Virus Infections
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Acyclovir
Valacyclovir Famciclovir Penciclovir Idoxuridine Docosanol |
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Acyclovir
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Metabolized into triphosphate cmpd by viral thymidine kinase
-potent inhibitor of DNA polymerase confined to use for herpesvirus |
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Valacyclovir, Famciclovir, Penciclovir
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similar to Acyclovir
More effective against herpes zoster. |
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Idoxuridine
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Phos'd into triphosphate.
-incorporated into viral DNA --strand breaks, ^mutation rate, miscoding Treats: -opthalmic herpesvirus infections -HSV -Keratitis |
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Docosanol
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Long-chain saturated alcohol
inhibits viral entry into cell OTC treatment of orolabial HSV (cold-sores) |
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Anti-Cytomegalovirus Drugs
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Ganciclovir
Foscarnet |
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Ganciclovir
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Similar to acyclovir.
Inhibits viral DNA polymerase Treats: -CMV-retinitis in AIDS patients -CMV infections in transplant patients Side FX: -CNS dysfunction -Teratogenic in animals |
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Foscarnet
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-100x greater inhibitor of viral DNA polymerase than cell DNA polymerase
Treats: -Ganciclovir-resistant CMV -Acyclovir-resistant HSV and VZV |
