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33 Cards in this Set
- Front
- Back
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What is MoA or SoA of acyclovir?
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structural analog of deoxyguanosine => blocks viral DNA polymerase
phosphorylated by viral TK |
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What is MoA or SoA of efavirenz?
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non-nucleotide reverse transcriptase inhibitor
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What is MoA or SoA of enfuvirtide?
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Entry inhibitor
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What is MoA or SoA of fosamprenavir?
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HIV protease inhibitor
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What is MoA or SoA of foscarnet?
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blocks viral DNA synthesis
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What is MoA or SoA of ganciclovir?
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blocks viral DNA synthesis
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What is MoA or SoA of interferon?
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regulates the Jak/STAT pathway
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What is MoA or SoA of lamivudine (3TC)?
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reverse transcriptase inhibitor
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What is MoA or SoA of oseltamivir (Tamiflu)?
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Neurominidase inhibitor
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What is MoA or SoA of raltegravir?
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inhibits HIV integrase
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What is MoA or SoA of ritonavir?
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HIV protease inhibitor
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What is MoA or SoA of telaprevir?
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inhibits Hepatitis C protease
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What is MoA or SoA of zidovudine (AZT)?
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reverse transcriptase inhibitor
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Which anti-virals are active against HIV?
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efavirenz (non-nucleotide RT inhibitor)
enfuviritide (fusion inhibitor) amprenavir (protease inhibitor) lamivudine (RT inhibitor) raltegravir (integrase inhibitor) ritonavir (protease inhibitor) zidovudine (AZT) (RT inhibitor) |
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Which anti-virals block viral DNA synthesis?
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foscarnet
ganciclovir |
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What are the adverse effects of efavirenz?
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CNS toxicity
skin rashes |
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What are the adverse effects of fosamprenavir?
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lipodystrophy
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What are the adverse effects of foscarnet?
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nephrotoxicity
hypocalcemia CNS toxicity |
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What are the adverse effects of ganciclovir?
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bone marrow toxicity
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What are the adverse effects of interferon?
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bone marrow depression
flu-like sx's |
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What are the adverse effects of oseltamivir (Tamiflu)?
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no major limiting toxicity
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What are the adverse effects of ritonavir?
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inhibits CYP3A4
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What are the adverse effects of zidovudine (AZT)?
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bone marrow depression
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Which anti-virals are administered orally?
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raltegravir
acyclovir lamivudine (3TC) zidovudine (AZT) efavirenz ritonavir oseltamivir (Tamiflu) fosamprenavir (ganciclovir) |
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Which anti-virals are administered parenterally?
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interferon
foscarnet enfuvirtide |
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Which anti-virals are eliminated by the kidney?
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acyclovir
lamivudine foscarnet ganciclovir zidovudine (AZT) (eliminated by kidney & liver) |
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Which anti-virals are eliminated by the liver?
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efavirenz
ritonavir oseltamivir (Tamiflu) (fos)amprenavir zidovudine (AZT) (eliminated by kidney & liver) |
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Which anti-virals can not get into the CSF (as opposed to default: in CSF)?
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oseltamivir (Tamiflu)
enfuvirtide |
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What are the uses of acyclovir?
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Primary herpes infxns (genital, encephalites, neonatal)
Chronic herpes (to reduce recurrence) |
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What are the resistance mechanisms to acyclovir?
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Mutations in viral TK gene
Viral DNA pol mutations |
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What are the uses of ganciclovir?
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CMV
Varicella zoster (chicken pox, shingles) |
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What are the uses of foscarnet?
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acyclovir/ganciclovir resistant HSV or CMV
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What are the uses of alpha interferon?
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genital warts (papillomavirus)
hep B hep C Kaposi's sarcoma (HSV VIII) |
