Anti-Psychotics

Front 1

What are the positive effects of anti-psychotics?

Back 1

Diminish positive symptoms: hallunciations, delusions, thought disorder.
Slightly diminish negative symptoms: blunted affect, lack of motivation, cognitive impairment.

Front 2

How do anti-psychotics basically work?

Back 2

Antagonise dopamine receptors, resulting in anti-psychotic effects.

Front 3

What are the indications for use of antipsychotics?

Back 3

Schizophrenia
Acute mania
Psychotic depression
Conventional
Atypical

Front 4

Name 5 conventional (typical) anti-psychotic drugs.

Back 4

Would the DOLL like a MAGAZINE and to fix all (THIXOL?)
Haloperidol.
Chlorpromazine.
Flupenhazine.
Flupenthixol.
Zuclopenthixol.

Front 5

Name 6 atypical antipsychotic drugs.

Back 5

I take PRIDE in having DONE a PINE tree to safe my SOUL (zole).
Amisulpride
Respiridone
Olanzapine
Clozapine
Quetiapine
Ariprazole

Front 6

Which has a greater effect on EPSE? Atypicals or typicals.

Back 6

Atypicals have a lower incidence of EPSE compared to typicals.

Front 7

Aside from dopamine receptors, which other neuroreceptors can antipsychotics effect?

Back 7

Acetylcholine, histamine and serotonin receptors.

Front 8

Which two atypical antipsychotic drugs are most likely to cause weight gain?

Back 8

Clozapine.
Olanzapine.

Front 9

Which three atypical antipsychotic drugs are most likely to cause increased serum lipids and impaired glucose tolerance?

Back 9

Clozapine.
Olanzapine.
Quetiapine.

Front 10

What are the anticholinergic side-effects?

Back 10

Dry mouth, blurred vision, constipation, urinary hesitancy.

Front 11

What are the physical manifestations of the side-effect of hyperprolactinaemia?

Back 11

Galactorrhoea
Amenorrhoea
Decreased libido
Sexual dysfunction

Front 12

What cardiac side-effect can be caused by anti-psychotic drugs?

Back 12

QTc prolongation.

Front 13

What is neuroleptic malignant syndrome?

Back 13

A potentially fatal side-effect of antipsychotic drugs. There are high-temperatures, muscled rigidity, altered conciousness, raised creatinine kinase.
Need to cease medication.
It can happen any time during treatment.

Front 14

What are the positive effects of anti-psychotics?

Back 14

Diminish positive symptoms: hallunciations, delusions, thought disorder.
Slightly diminish negative symptoms: blunted affect, lack of motivation, cognitive impairment.

Front 15

How do anti-psychotics basically work?

Back 15

Antagonise dopamine receptors, resulting in anti-psychotic effects.

Front 16

What are the indications for use of antipsychotics?

Back 16

Schizophrenia
Acute mania
Psychotic depression
Conventional
Atypical

Front 17

Name 5 conventional (typical) anti-psychotic drugs.

Back 17

Would the DOLL like a MAGAZINE and to fix all (THIXOL?)
Haloperidol.
Chlorpromazine.
Flupenhazine.
Flupenthixol.
Zuclopenthixol.

Front 18

Name 6 atypical antipsychotic drugs.

Back 18

I take PRIDE in having DONE a PINE tree to safe my SOUL (zole).
Amisulpride
Respiridone
Olanzapine
Clozapine
Quetiapine
Ariprazole

Front 19

Which has a greater effect on EPSE? Atypicals or typicals.

Back 19

Atypicals have a lower incidence of EPSE compared to typicals.

Front 20

Aside from dopamine receptors, which other neuroreceptors can antipsychotics effect?

Back 20

Acetylcholine, histamine and serotonin receptors.

Front 21

Which two atypical antipsychotic drugs are most likely to cause weight gain?

Back 21

Clozapine.
Olanzapine.

Front 22

Which three atypical antipsychotic drugs are most likely to cause increased serum lipids and impaired glucose tolerance?

Back 22

Clozapine.
Olanzapine.
Quetiapine.

Front 23

Which typical drugs can be used as depot antipsychotics?

Back 23

Zuclopenthixol, Flupenthixol, Flupenhazine.
Zuclopenthixol - good for agitated, disturbed, aggressive behaviour.
Flupenthixol - may have mood elevating effects.
Flupenhazine - EPSE common.

Front 24

Which atypical drugs can be used as depot antipsychotics?

Back 24

Risperidone - called Risperdal Consta.
Onset of action is 3 weeks, therefore need oral respiridone to supplement until peak plasma is reached.

Front 25

Which drugs are most likely to cause hyper-prolactinaemia?

Back 25

Risperidone, paliperidone.

Front 26

Which drug never causes hyper-prolactinaemia?

Back 26

Asenapine.

Front 27

Which drugs are most likely to cause weight gain?

Back 27

Olanzapine, clozapine, chlorpromazine.

Front 28

Which drugs never cause weight gain?

Back 28

Ziprasidone, asenapine, sertindole.

Front 29

Which drugs are most likely to cause postural hypotension?

Back 29

Clozapine, chlorpromazine, risperidone depot.

Front 30

Which drugs have no anticholinergic side-effects?

Back 30

Amisulpride.
Amiprazole.
Risperidone.
Paliperidone.

Front 31

What are the acute EPSE?

Back 31

Akithesia
Dystonia
Tremor
Parkinsonism (shuffling gait, reduced arm swing, mask-like facial features, retropulsion, tremor, cog-wheel rigidity)
Tremor

Front 32

What are the tardive EPSE?

Back 32

Tardive dyskinesia: involuntary hyperkinetic movements such as lip-smacking, jaw-writing, chewing, tick-like movments.
Tardive akithisa.
Tardive dystonia.

Front 33

What is the management of acute EPSE?

Back 33

Reduce dose or change medication if possible.
Can give anticholinergic medication: benztropine 1-2 mg orally, benzhexol 2 - 5mg orally?

Front 34

How is akithisia best managed?

Back 34

Beta-blockers, e.g. propanolol.
Benzodiazepines, e.g. diazepam.

Front 35

How do you manage tardive EPS?

Back 35

Benzodiazepines can provide some relief.
Changing to an atypical, e.g. clozapine, can help.
May resolve spontaneously.