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6 Cards in this Set

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  • Back
What is the most common cause of death in TCA overdose.
Refractory hypotension and arrythmia
What do the TCA inhibit?
Presynaptic NT reuptake: tremor, insomnia
CARDIAC FAST Na Channels(MCC OF DEATH IN INTOXICATION; tx: hypertonic NaHCO3-): Cardiac condxn, arrythmia, hypotension
CENTRAL AND PERIPHERAL MUSCARINICS: hyperthermia, flushing, dialated pupils, ileus, sinus tachycardia, urinary retention
PERIPHERAL ALPHA-1: VD, ortho hyp
H1: sedation
What are the TCA MOA?
block reuptake of NE and 5HT
What are the TCA?
Imipramine (bed wetting)
amityptaline
Clomipramine(OCD)

despiramine, nortiptyline(these are secondary structured, so less side effects)
Doxepine, amoxapine
What are the major A/E of TCA?
SEDATION, alpha blocking, anticholinergic (tachy, urine retention), CCC (cardiotoxicty(arrythmia-qunidien like, blocks fast Na channels), coma, convulsions(despiramine is the worst))
TCA uses?
Depression, bedwetting(imipramine), OCD (clomipramine), fibromyalgia, DM Neuropathy!