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6 Cards in this Set
- Front
- Back
What is the most common cause of death in TCA overdose.
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Refractory hypotension and arrythmia
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What do the TCA inhibit?
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Presynaptic NT reuptake: tremor, insomnia
CARDIAC FAST Na Channels(MCC OF DEATH IN INTOXICATION; tx: hypertonic NaHCO3-): Cardiac condxn, arrythmia, hypotension CENTRAL AND PERIPHERAL MUSCARINICS: hyperthermia, flushing, dialated pupils, ileus, sinus tachycardia, urinary retention PERIPHERAL ALPHA-1: VD, ortho hyp H1: sedation |
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What are the TCA MOA?
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block reuptake of NE and 5HT
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What are the TCA?
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Imipramine (bed wetting)
amityptaline Clomipramine(OCD) despiramine, nortiptyline(these are secondary structured, so less side effects) Doxepine, amoxapine |
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What are the major A/E of TCA?
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SEDATION, alpha blocking, anticholinergic (tachy, urine retention), CCC (cardiotoxicty(arrythmia-qunidien like, blocks fast Na channels), coma, convulsions(despiramine is the worst))
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TCA uses?
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Depression, bedwetting(imipramine), OCD (clomipramine), fibromyalgia, DM Neuropathy!
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