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11 Cards in this Set
- Front
- Back
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Carbidopa mechanism
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reversible inhibitor of amino acid decarboxylase (decarboxylates L-DOPA)
doesn't enter brain |
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clinical use of carbidopa
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prevent adverse effx of L-DOPA
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domperidone mechanism
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dopamine antagoinist; does not cross blood brain barrier
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bromocriptine, mechanism
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directly stimulates dopamine receptor
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bromocriptine; problemas
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efectos secundarios similar to L DOPA
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Anticholinergics; clinical use for parkinson
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"restore" dopamine/Ach balance. helpful for tremor (not good for older pts)
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Amantadine, clinical use/efx
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mild direct dopamine agonist; blocks dopamine reuptake
symptomatic tx of parkinsons |
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selegine mechanism
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selective irreversible inhibiter of MAO type B.
block CNS dopamine metabolism |
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L DOPA effect duration and therapeutic window as parkinsons progresses
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therapeutic window narrows
duration of response shortens |
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tolcapone mechanism
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blocks metabolism of dopamine
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entacapone mechanosm
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block metabolism of dopamine
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