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20 Cards in this Set

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Cyclosporine
Protects against rejections from organ transplants
81. Does not induce bone marrow depression
Cyclophosphamide
Alkylating agent of both purine & pyrimidine bases of DNA
83. Txt CLL
Cisplatin’s toxicities
Nephro- & Ototoxicity
Methotrexate
Antimetabolite of folic acid: (-)dihydrofolate reductase
Leucovorin Rescue
Can block/reduce Methotrexate = ↑ folic acid via a reduced folate
Bleomycin toxicities
Pneumonitis & pulmonary fibrosis
Azathiorine
Used in organ transplantation = kidney allografts
89. Allopurinol can ↑ its activity by (-) its biotransformation to xanthine oxidase
MOPP
Chemotherapy used in the txt of Hodgkin’s disease
91. M = Mechlorethamine – nitrogen mustard
92. O = Oncovin (Vincristine) – prevents microtubule assembly
93. P = Procarbazine
94. P = Prednisone – glucocorticoid, inducing apoptosis
Tamoxifen
(-) estrogen receptor
96. Txt of breast tumors, can see associated endometrial CA
Flutamide
Antiandrogenic
98. Used w/ Leuprolide (LH-RH analog)
99. Txt prostatic CA
Megestrol
(-) progesterone receptor
101. Txt endometrial CA
Fluoxymesterone
Androgenic steroid
103. Txt mammary CA in postmenopausal women
Methotrexate
Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase
105. Txt of ALL
106. Txt of Psoriasis
Brain tumor Txt
Lomustine
108. Carmustine – Causes pulmonary fibrosis
Streptozocin
Attaches to β cells
110. Txt of pancreatic insulinomas
Cytarabine (AraC)
Pyrimidine analog
112. DOC for AML
Dactinomycin
Used for Wilms tumor & rhabdomyosarcoma
Etoposide
Used for oat cell CA
Paclitaxel
Used for ovarian CA
Amifostine
Can ↓ nephrotoxicity due to chronic use of Cisplatin