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20 Cards in this Set
- Front
- Back
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Cyclosporine
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Protects against rejections from organ transplants
81. Does not induce bone marrow depression |
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Cyclophosphamide
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Alkylating agent of both purine & pyrimidine bases of DNA
83. Txt CLL |
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Cisplatin’s toxicities
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Nephro- & Ototoxicity
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Methotrexate
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Antimetabolite of folic acid: (-)dihydrofolate reductase
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Leucovorin Rescue
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Can block/reduce Methotrexate = ↑ folic acid via a reduced folate
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Bleomycin toxicities
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Pneumonitis & pulmonary fibrosis
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Azathiorine
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Used in organ transplantation = kidney allografts
89. Allopurinol can ↑ its activity by (-) its biotransformation to xanthine oxidase |
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MOPP
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Chemotherapy used in the txt of Hodgkin’s disease
91. M = Mechlorethamine – nitrogen mustard 92. O = Oncovin (Vincristine) – prevents microtubule assembly 93. P = Procarbazine 94. P = Prednisone – glucocorticoid, inducing apoptosis |
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Tamoxifen
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(-) estrogen receptor
96. Txt of breast tumors, can see associated endometrial CA |
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Flutamide
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Antiandrogenic
98. Used w/ Leuprolide (LH-RH analog) 99. Txt prostatic CA |
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Megestrol
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(-) progesterone receptor
101. Txt endometrial CA |
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Fluoxymesterone
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Androgenic steroid
103. Txt mammary CA in postmenopausal women |
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Methotrexate
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Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase
105. Txt of ALL 106. Txt of Psoriasis |
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Brain tumor Txt
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Lomustine
108. Carmustine – Causes pulmonary fibrosis |
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Streptozocin
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Attaches to β cells
110. Txt of pancreatic insulinomas |
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Cytarabine (AraC)
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Pyrimidine analog
112. DOC for AML |
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Dactinomycin
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Used for Wilms tumor & rhabdomyosarcoma
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Etoposide
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Used for oat cell CA
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Paclitaxel
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Used for ovarian CA
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Amifostine
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Can ↓ nephrotoxicity due to chronic use of Cisplatin
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