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23 Cards in this Set
- Front
- Back
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What are the four major symptoms of inflammation?
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Redness
pain heat swelling |
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What is inflammation triggered by?
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tissue damage due to infection, heat, wound,etc.
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What is the good COX?
What is the bad COX? |
COX-1, housekeepers
COX-2 |
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What does COX-1 do?
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Protects gastric mucosa
Supports renal function Promotes platelet aggregation |
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What does COX-2 do?
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Tissue inflammation sites
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What does a COX-1 inhibitors do?
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Gastric erosion & bleeding
Bleeding tendencies Renal impairment Protection against MI |
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What does a COX-2 inhibitors do?
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inflammation suppression
Pain relief fever reduction |
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What are 1st generation NSAIDS? what do they inhibit?
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ASA, Ibuprofen, Naproxen, Ketrolac(only IV), Indomethacin
COX 1&2 |
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What is the 2nd generation of NSAIDS? what do they inhibit?
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Celecoxib
only inhibit COX-2 |
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Are 1st generation NSIADS better/safer then 2nd generation?
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no
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What is the most significant S.E. of NSAIDS?
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Gastrointestinal Ulceration
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How do we limit Gastrointestinal Ulceration when using NSAIDS?
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We co-administrate of misoprostol, a synthetic PGE1 analog decreases GI bleeding
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What does ASA cause an irreversible inhibition of?
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COX 1&2
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Why don't you give children ASA?
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Reye's Syndrome
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How are ASA excreted?
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Renal
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A single dose of aspirin approximately ______ the mean bleeding time of normal persons for a period of ______ ?
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doubles
4-7 days |
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What are drug interactions with ASA?
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Warfarin, Glucocorticoids, ETOH, Ibuprofen
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How do you treat overdose of ASA?
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Gastric lavage
Charcoal IV to restore pH, fluids, and electrolytes Dialysis |
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What is not considered a true NSAID?
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Acetaminophen
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Overdose is the leading cause of ___________ in US. Can it be fatal?
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acute liver failure
yes |
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What can you give to neutralize Acetaminophen?
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N-acetylcysteine
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What does COX stand for?
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cyclooxygenase
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What does COX do?
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enzyme that converts arachidonic acid into prostaglandins in all tissues
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