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5 Cards in this Set

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Penicillins - Mechanism of Resistance
1. formation of beta-lactamases (penicillinase);
2. structural alterations in penicillin-binding proteins (PBPs)
Macrolides - Mechanism of Resistance
production of methylase that adds a methyl group to the ribosomal drug-binding site
Aminoglycosides - Mechanism of Resistance
plasmid-mediated production of inactivating enzymes, such as enzymes that phosphorylate, adenylate or acetylate the drug.
Anaerobes are naturally resistant because these drugs are taken up into bacteria by an oxygen-dependent transport system
Fluroquinolones - Mechanism of Resistance
1. decreased ability to accumulate the drug;
2. mutation in the target enzyme's fluoroquinolone-binding site
Vancomycin - Mechanism of Resistance
replacement of terminal D-ala by D-lactate at the drug-binding site