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20 Cards in this Set
- Front
- Back
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What is MoA or SoA of amphotericin B?
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causes membrane permeability pores
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What is MoA or SoA of caspofungin?
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inhibits beta-glucan synthase
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What is MoA or SoA of fluconazole?
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inhibits ergosterol biosynthesis
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What is MoA or SoA of flucytosine?
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forms fluorouracil in cell and inhibits thymidylate synthetase and DNA syn.
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What is MoA or SoA of itraconazole?
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inhibits ergosterol biosynthesis
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What is MoA or SoA of voriconazole?
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inhibits ergosterol biosynthesis
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What are the adverse effects of amphotericin B?
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nephrotoxicity
fever chills |
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What are the adverse effects of caspofungin?
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headache
GI distress histamine release |
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What are the adverse effects of flucytosine?
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rarely, bone marrow depression
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What are the adverse effects of voriconazole?
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visual disturbances
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Which anti-fungals are administered parenterally?
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amphotericin B
caspofungin |
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Which anti-fungals are administered orally?
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fluconazole
flucytosine itraconazole voriconazole |
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Which anti-fungals are excreted by the kidney?
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fluconazole
flucytosine |
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Which anti-fungals are excreted by the liver?
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caspofungin
itraconazole voriconazole |
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Which anti-fungals can be found in the CSF?
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fluconazole
flucytosine voriconazole |
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Which anti-fungals are not found in the CSF?
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amphotericin B
caspofungin itraconazole |
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What are the triazole anti-fungal drugs?
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Selectively inhibit fungal CYP34A (req'd for ergosterol biosynthesis)
fluconazole itraconazole voriconazole |
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How do fungi become resistant to triazoles?
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most: MDR efflux pumps
also: mutations/overproduction of 14-alpha-demethylase |
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How do fungi become resistant to flucytosine?
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Common: mutation in permease, deaminase, or pyrophosphorylase
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What are the treatment options for aspergillosis?
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Gold std. traditionally: amphotericin B
New primary therapy: triazoles Salvage therapy: caspofungin |
